4OFF

Crystal structure of apo carboxy cGMP binding domain of Plasmodium falciparum PKG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005952	cellular_component	cAMP-dependent protein kinase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 601

Chain	Residue
A	ARG435
A	THR436
A	HOH708
A	HOH741
A	HOH745

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 602

Chain	Residue
A	THR423
A	ASP424
A	LYS499

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 603

Chain	Residue
A	SER453
A	ARG454
A	TYR456
A	ARG492
A	HOH705
A	HOH709
A	GLY452

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 604

Chain	Residue
A	GLU490
A	ARG492
A	THR493
A	HIS524
A	LEU525
A	HOH748

---

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIqEGEvGSrFYIIknG

Chain	Residue	Details
A	ILE445-GLY461

---

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGErALlydep......RTAsViS

Chain	Residue	Details
A	PHE481-SER498

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	99
Details	Region: {"description":"cNMP-binding domain 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00060","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8I719","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Part of a catalytic triad required for cGMP binding and cGMP-dependent kinase activity","evidences":[{"source":"UniProtKB","id":"Q8I719","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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