4OC9

2.35 Angstrom resolution crystal structure of putative O-acetylhomoserine (thiol)-lyase (metY) from Campylobacter jejuni subsp. jejuni NCTC 11168 with N'-Pyridoxyl-Lysine-5'-Monophosphate at position 205

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
A	0004124	molecular_function	cysteine synthase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0019344	biological_process	L-cysteine biosynthetic process
A	0019346	biological_process	transsulfuration
A	0030170	molecular_function	pyridoxal phosphate binding
A	0071266	biological_process	'de novo' L-methionine biosynthetic process
A	0071269	biological_process	L-homocysteine biosynthetic process
B	0003824	molecular_function	catalytic activity
B	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
B	0004124	molecular_function	cysteine synthase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0019344	biological_process	L-cysteine biosynthetic process
B	0019346	biological_process	transsulfuration
B	0030170	molecular_function	pyridoxal phosphate binding
B	0071266	biological_process	'de novo' L-methionine biosynthetic process
B	0071269	biological_process	L-homocysteine biosynthetic process
C	0003824	molecular_function	catalytic activity
C	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
C	0004124	molecular_function	cysteine synthase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0019344	biological_process	L-cysteine biosynthetic process
C	0019346	biological_process	transsulfuration
C	0030170	molecular_function	pyridoxal phosphate binding
C	0071266	biological_process	'de novo' L-methionine biosynthetic process
C	0071269	biological_process	L-homocysteine biosynthetic process
D	0003824	molecular_function	catalytic activity
D	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
D	0004124	molecular_function	cysteine synthase activity
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0019344	biological_process	L-cysteine biosynthetic process
D	0019346	biological_process	transsulfuration
D	0030170	molecular_function	pyridoxal phosphate binding
D	0071266	biological_process	'de novo' L-methionine biosynthetic process
D	0071269	biological_process	L-homocysteine biosynthetic process
E	0003824	molecular_function	catalytic activity
E	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
E	0004124	molecular_function	cysteine synthase activity
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
E	0019344	biological_process	L-cysteine biosynthetic process
E	0019346	biological_process	transsulfuration
E	0030170	molecular_function	pyridoxal phosphate binding
E	0071266	biological_process	'de novo' L-methionine biosynthetic process
E	0071269	biological_process	L-homocysteine biosynthetic process
F	0003824	molecular_function	catalytic activity
F	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
F	0004124	molecular_function	cysteine synthase activity
F	0005737	cellular_component	cytoplasm
F	0006520	biological_process	amino acid metabolic process
F	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
F	0019344	biological_process	L-cysteine biosynthetic process
F	0019346	biological_process	transsulfuration
F	0030170	molecular_function	pyridoxal phosphate binding
F	0071266	biological_process	'de novo' L-methionine biosynthetic process
F	0071269	biological_process	L-homocysteine biosynthetic process
G	0003824	molecular_function	catalytic activity
G	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
G	0004124	molecular_function	cysteine synthase activity
G	0005737	cellular_component	cytoplasm
G	0006520	biological_process	amino acid metabolic process
G	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
G	0019344	biological_process	L-cysteine biosynthetic process
G	0019346	biological_process	transsulfuration
G	0030170	molecular_function	pyridoxal phosphate binding
G	0071266	biological_process	'de novo' L-methionine biosynthetic process
G	0071269	biological_process	L-homocysteine biosynthetic process
H	0003824	molecular_function	catalytic activity
H	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
H	0004124	molecular_function	cysteine synthase activity
H	0005737	cellular_component	cytoplasm
H	0006520	biological_process	amino acid metabolic process
H	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
H	0019344	biological_process	L-cysteine biosynthetic process
H	0019346	biological_process	transsulfuration
H	0030170	molecular_function	pyridoxal phosphate binding
H	0071266	biological_process	'de novo' L-methionine biosynthetic process
H	0071269	biological_process	L-homocysteine biosynthetic process
I	0003824	molecular_function	catalytic activity
I	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
I	0004124	molecular_function	cysteine synthase activity
I	0005737	cellular_component	cytoplasm
I	0006520	biological_process	amino acid metabolic process
I	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
I	0019344	biological_process	L-cysteine biosynthetic process
I	0019346	biological_process	transsulfuration
I	0030170	molecular_function	pyridoxal phosphate binding
I	0071266	biological_process	'de novo' L-methionine biosynthetic process
I	0071269	biological_process	L-homocysteine biosynthetic process
J	0003824	molecular_function	catalytic activity
J	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
J	0004124	molecular_function	cysteine synthase activity
J	0005737	cellular_component	cytoplasm
J	0006520	biological_process	amino acid metabolic process
J	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
J	0019344	biological_process	L-cysteine biosynthetic process
J	0019346	biological_process	transsulfuration
J	0030170	molecular_function	pyridoxal phosphate binding
J	0071266	biological_process	'de novo' L-methionine biosynthetic process
J	0071269	biological_process	L-homocysteine biosynthetic process
K	0003824	molecular_function	catalytic activity
K	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
K	0004124	molecular_function	cysteine synthase activity
K	0005737	cellular_component	cytoplasm
K	0006520	biological_process	amino acid metabolic process
K	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
K	0019344	biological_process	L-cysteine biosynthetic process
K	0019346	biological_process	transsulfuration
K	0030170	molecular_function	pyridoxal phosphate binding
K	0071266	biological_process	'de novo' L-methionine biosynthetic process
K	0071269	biological_process	L-homocysteine biosynthetic process
L	0003824	molecular_function	catalytic activity
L	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
L	0004124	molecular_function	cysteine synthase activity
L	0005737	cellular_component	cytoplasm
L	0006520	biological_process	amino acid metabolic process
L	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
L	0019344	biological_process	L-cysteine biosynthetic process
L	0019346	biological_process	transsulfuration
L	0030170	molecular_function	pyridoxal phosphate binding
L	0071266	biological_process	'de novo' L-methionine biosynthetic process
L	0071269	biological_process	L-homocysteine biosynthetic process
M	0003824	molecular_function	catalytic activity
M	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
M	0004124	molecular_function	cysteine synthase activity
M	0005737	cellular_component	cytoplasm
M	0006520	biological_process	amino acid metabolic process
M	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
M	0019344	biological_process	L-cysteine biosynthetic process
M	0019346	biological_process	transsulfuration
M	0030170	molecular_function	pyridoxal phosphate binding
M	0071266	biological_process	'de novo' L-methionine biosynthetic process
M	0071269	biological_process	L-homocysteine biosynthetic process
N	0003824	molecular_function	catalytic activity
N	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
N	0004124	molecular_function	cysteine synthase activity
N	0005737	cellular_component	cytoplasm
N	0006520	biological_process	amino acid metabolic process
N	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
N	0019344	biological_process	L-cysteine biosynthetic process
N	0019346	biological_process	transsulfuration
N	0030170	molecular_function	pyridoxal phosphate binding
N	0071266	biological_process	'de novo' L-methionine biosynthetic process
N	0071269	biological_process	L-homocysteine biosynthetic process
O	0003824	molecular_function	catalytic activity
O	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
O	0004124	molecular_function	cysteine synthase activity
O	0005737	cellular_component	cytoplasm
O	0006520	biological_process	amino acid metabolic process
O	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
O	0019344	biological_process	L-cysteine biosynthetic process
O	0019346	biological_process	transsulfuration
O	0030170	molecular_function	pyridoxal phosphate binding
O	0071266	biological_process	'de novo' L-methionine biosynthetic process
O	0071269	biological_process	L-homocysteine biosynthetic process
P	0003824	molecular_function	catalytic activity
P	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
P	0004124	molecular_function	cysteine synthase activity
P	0005737	cellular_component	cytoplasm
P	0006520	biological_process	amino acid metabolic process
P	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
P	0019344	biological_process	L-cysteine biosynthetic process
P	0019346	biological_process	transsulfuration
P	0030170	molecular_function	pyridoxal phosphate binding
P	0071266	biological_process	'de novo' L-methionine biosynthetic process
P	0071269	biological_process	L-homocysteine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IMD A 501

Chain	Residue
A	PHE305
A	HOH675
E	ASP334
E	HOH556

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 502

Chain	Residue
D	TYR53
D	ARG267
A	TYR108
A	ALA366
A	THR382
A	HOH628
A	HOH709

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 501

Chain	Residue
B	GLU300
B	ASN336
B	HOH636
B	HOH707
B	HOH779
G	ASP311
G	GLU422

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 C 501

Chain	Residue
C	GLU300
C	ASN336
C	HOH656
H	ASP311

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IMD D 501

Chain	Residue
D	ASP311
D	HOH765
F	GLU300
F	ASN336

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL O 501

Chain	Residue
O	SER54
O	LEU56
O	SER61
O	PRO79
O	LEU266
O	SER272
O	LEU273
O	HOH612
O	HOH747

---