Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4OBU

Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (apo)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006568	biological_process	tryptophan metabolic process
A	0016830	molecular_function	carbon-carbon lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0019752	biological_process	carboxylic acid metabolic process
A	0030170	molecular_function	pyridoxal phosphate binding
A	0036469	molecular_function	L-tryptophan decarboxylase activity
B	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006568	biological_process	tryptophan metabolic process
B	0016830	molecular_function	carbon-carbon lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0019752	biological_process	carboxylic acid metabolic process
B	0030170	molecular_function	pyridoxal phosphate binding
B	0036469	molecular_function	L-tryptophan decarboxylase activity
C	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006568	biological_process	tryptophan metabolic process
C	0016830	molecular_function	carbon-carbon lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0019752	biological_process	carboxylic acid metabolic process
C	0030170	molecular_function	pyridoxal phosphate binding
C	0036469	molecular_function	L-tryptophan decarboxylase activity
E	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0006568	biological_process	tryptophan metabolic process
E	0016830	molecular_function	carbon-carbon lyase activity
E	0016831	molecular_function	carboxy-lyase activity
E	0019752	biological_process	carboxylic acid metabolic process
E	0030170	molecular_function	pyridoxal phosphate binding
E	0036469	molecular_function	L-tryptophan decarboxylase activity
F	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
F	0005737	cellular_component	cytoplasm
F	0006520	biological_process	amino acid metabolic process
F	0006568	biological_process	tryptophan metabolic process
F	0016830	molecular_function	carbon-carbon lyase activity
F	0016831	molecular_function	carboxy-lyase activity
F	0019752	biological_process	carboxylic acid metabolic process
F	0030170	molecular_function	pyridoxal phosphate binding
F	0036469	molecular_function	L-tryptophan decarboxylase activity
G	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
G	0005737	cellular_component	cytoplasm
G	0006520	biological_process	amino acid metabolic process
G	0006568	biological_process	tryptophan metabolic process
G	0016830	molecular_function	carbon-carbon lyase activity
G	0016831	molecular_function	carboxy-lyase activity
G	0019752	biological_process	carboxylic acid metabolic process
G	0030170	molecular_function	pyridoxal phosphate binding
G	0036469	molecular_function	L-tryptophan decarboxylase activity
H	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
H	0005737	cellular_component	cytoplasm
H	0006520	biological_process	amino acid metabolic process
H	0006568	biological_process	tryptophan metabolic process
H	0016830	molecular_function	carbon-carbon lyase activity
H	0016831	molecular_function	carboxy-lyase activity
H	0019752	biological_process	carboxylic acid metabolic process
H	0030170	molecular_function	pyridoxal phosphate binding
H	0036469	molecular_function	L-tryptophan decarboxylase activity
U	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
U	0005737	cellular_component	cytoplasm
U	0006520	biological_process	amino acid metabolic process
U	0006568	biological_process	tryptophan metabolic process
U	0016830	molecular_function	carbon-carbon lyase activity
U	0016831	molecular_function	carboxy-lyase activity
U	0019752	biological_process	carboxylic acid metabolic process
U	0030170	molecular_function	pyridoxal phosphate binding
U	0036469	molecular_function	L-tryptophan decarboxylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP E 501

Chain	Residue
E	PHE98
E	LYS306
E	TYR312
E	HOH612
H	THR356
E	GLY159
E	SER160
E	HIS192
E	GLY247
E	THR249
E	ASP274
E	ALA276
E	ASP303

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP A 501

Chain	Residue
A	PHE98
A	GLY159
A	SER160
A	HIS192
A	GLY247
A	THR249
A	ASP274
A	ALA276
A	ASP303
A	LYS306
A	TYR312
A	HOH628
U	THR356

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PLP U 501

Chain	Residue
A	THR356
U	PHE98
U	GLY159
U	SER160
U	HIS192
U	GLY247
U	THR249
U	ASP274
U	ALA276
U	LYS306
U	TYR312

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP G 501

Chain	Residue
F	THR356
F	HOH608
G	PHE98
G	GLY159
G	SER160
G	HIS192
G	GLY247
G	THR249
G	ASP274
G	ALA276
G	ASP303
G	LYS306
G	TYR312

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP H 501

Chain	Residue
E	THR356
H	PHE98
H	GLY159
H	SER160
H	HIS192
H	GLY247
H	THR249
H	ASP274
H	ALA276
H	LYS306
H	TYR312
H	HOH639
H	HOH640

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP F 501

Chain	Residue
F	PHE98
F	GLY159
F	SER160
F	HIS192
F	GLY247
F	THR249
F	ASP274
F	ALA276
F	ASP303
F	LYS306
F	TYR312
F	HOH632
G	THR356

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PLP B 501

Chain	Residue
B	PHE98
B	GLY159
B	SER160
B	HIS192
B	GLY247
B	THR249
B	ASP274
B	ALA276
B	LYS306
B	TYR312
C	THR356

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PLP C 501

Chain	Residue
B	THR356
C	PHE98
C	GLY159
C	SER160
C	HIS192
C	THR249
C	ASP274
C	ALA276
C	ASP303
C	LYS306
C	TYR312

Functional Information from PROSITE/UniProt

site_id	PS00392
Number of Residues	22
Details	DDC_GAD_HDC_YDC DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. SIsWdahKWLfQtYGCamVLvK

Chain	Residue	Details
E	SER299-LYS320

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269\|PubMed:25263219

Chain	Residue	Details
E	LYS306
A	LYS306
U	LYS306
G	LYS306
H	LYS306
F	LYS306
B	LYS306
C	LYS306

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)