4OBR

Crystal structure of human alpha-L-iduronidase complex with alpha-L-iduronic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0005975	biological_process	carbohydrate metabolic process
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0005975	biological_process	carbohydrate metabolic process

Functional Information from PROSITE/UniProt

site_id	PS01027
Number of Residues	10
Details	GLYCOSYL_HYDROL_F39 Glycosyl hydrolases family 39 active site. WnFEtWNEPD

Chain	Residue	Details
A	TRP175-ASP184

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10068","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24036510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"24036510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23959878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24036510","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KGL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23959878","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W82","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23959878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24036510","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KGJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KH2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23959878","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W82","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23959878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24036510","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KGJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MJ4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23959878","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W82","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23959878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24036510","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KGJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MJ4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23959878","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W81","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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