4OBP

MAP4K4 in complex with inhibitor (compound 29), 6-(2-FLUOROPYRIDIN-4-YL)PYRIDO[3,2-D]PYRIMIDIN-4-AMINE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 401

Chain	Residue
A	SER77
A	HIS79
A	ILE82
A	THR84
A	HOH632

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MES A 402

Chain	Residue
A	GLN282
A	HOH627
A	HOH631
A	HOH656
B	MET275
B	GLN276
A	MET275
A	GLN276
A	ARG277
A	PRO278

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 2QU A 403

Chain	Residue
A	TYR36
A	ALA52
A	LYS54
A	GLU69
A	MET105
A	GLU106
A	PHE107
A	CYS108
A	LEU160
A	ASP171
A	HOH559
A	HOH560
A	HOH649

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGNGTYGQVYkGrhvktgql..........AAIK

Chain	Residue	Details
A	VAL31-LYS54

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKgqNVLL

Chain	Residue	Details
A	VAL149-LEU161

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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