4OB3

Crystal Structure of Nitrile Hydratase from Pseudonocardia thermophila : A Reference Structure to Boronic Acid Inhibition of Nitrile Hydratase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0016829	molecular_function	lyase activity
A	0018822	molecular_function	nitrile hydratase activity
A	0046872	molecular_function	metal ion binding
A	0046914	molecular_function	transition metal ion binding
A	0050897	molecular_function	cobalt ion binding
A	0050899	biological_process	nitrile catabolic process
B	0005515	molecular_function	protein binding
B	0016829	molecular_function	lyase activity
B	0018822	molecular_function	nitrile hydratase activity
B	0046914	molecular_function	transition metal ion binding
B	0050899	biological_process	nitrile catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO A 301

Chain	Residue
A	CYS108
A	CSD111
A	SER112
A	CSO113
A	HOH494

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 301

Chain	Residue
B	TYR222
B	ILE223
B	GLU224
B	HOH557
B	ARG146
B	PHE147
B	SER148
B	PRO221

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:11700034

Chain	Residue	Details
A	CYS108
A	CSD111
A	SER112
A	CSO113

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Cysteine sulfinic acid (-SO2H) => ECO:0000269|PubMed:11700034

Chain	Residue	Details
A	CSD111

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Cysteine sulfenic acid (-SOH) => ECO:0000269|PubMed:11700034

Chain	Residue	Details
A	CSO113

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