4O9C

Crystal structure of Beta-ketothiolase (PhaA) from Ralstonia eutropha H16

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
A	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0042619	biological_process	poly-hydroxybutyrate biosynthetic process
A	0044281	biological_process	small molecule metabolic process
B	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
B	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0042619	biological_process	poly-hydroxybutyrate biosynthetic process
B	0044281	biological_process	small molecule metabolic process
C	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
C	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0042619	biological_process	poly-hydroxybutyrate biosynthetic process
C	0044281	biological_process	small molecule metabolic process
D	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
D	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0042619	biological_process	poly-hydroxybutyrate biosynthetic process
D	0044281	biological_process	small molecule metabolic process
E	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
E	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0042619	biological_process	poly-hydroxybutyrate biosynthetic process
E	0044281	biological_process	small molecule metabolic process
F	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
F	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0042619	biological_process	poly-hydroxybutyrate biosynthetic process
F	0044281	biological_process	small molecule metabolic process
G	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
G	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
G	0005737	cellular_component	cytoplasm
G	0016740	molecular_function	transferase activity
G	0016746	molecular_function	acyltransferase activity
G	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
G	0042619	biological_process	poly-hydroxybutyrate biosynthetic process
G	0044281	biological_process	small molecule metabolic process
H	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
H	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
H	0005737	cellular_component	cytoplasm
H	0016740	molecular_function	transferase activity
H	0016746	molecular_function	acyltransferase activity
H	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
H	0042619	biological_process	poly-hydroxybutyrate biosynthetic process
H	0044281	biological_process	small molecule metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE COA C 401

Chain	Residue
C	SER88
C	ALA319
C	PHE320
C	HIS349
C	HOH513
H	MET134
C	LEU148
C	HIS156
C	ARG221
C	PHE236
C	ALA244
C	SER248
C	GLY249
C	LEU250

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Functional Information from PROSITE/UniProt

site_id	PS00099
Number of Residues	14
Details	THIOLASE_3 Thiolases active site. GLASLCIGgGmGvA

Chain	Residue	Details
A	GLY374-ALA387

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site_id	PS00737
Number of Residues	17
Details	THIOLASE_2 Thiolases signature 2. NvnGGaIAiGHPiGaSG

Chain	Residue	Details
A	ASN339-GLY355

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Acyl-thioester intermediate","evidences":[{"source":"PubMed","id":"25152395","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10020","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25152395","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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