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4O8J

Crystal structure of RtcA, the RNA 3'-terminal phosphate cyclase from Pyrococcus horikoshii, in complex with rACAAA3'phosphate and adenine.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0003963molecular_functionRNA-3'-phosphate cyclase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0006396biological_processRNA processing
A0016874molecular_functionligase activity
B0003824molecular_functioncatalytic activity
B0003963molecular_functionRNA-3'-phosphate cyclase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0006396biological_processRNA processing
B0016874molecular_functionligase activity
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ADN A 401
ChainResidue
AGLN14
AHIS307
EA6
AARG17
ALEU97
AGLN100
APRO127
AASP250
APHE283
AASP286
AGLN287

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ADN B 401
ChainResidue
BGLN14
BLEU97
BGLN100
BSER126
BPRO127
BASP250
BPHE283
BASP286
BGLN287
BHIS307
BHOH740

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE EPE B 402
ChainResidue
BVAL63
BLYS64
BGLY65
BALA66
BLYS180
BGLU181
BTRP300
BHOH707
BHOH711

Functional Information from PROSITE/UniProt
site_idPS01287
Number of Residues11
DetailsRTC RNA 3'-terminal phosphate cyclase signature. RGhyPkGGGiV
ChainResidueDetails
AARG154-VAL164

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Tele-AMP-histidine intermediate => ECO:0000250
ChainResidueDetails
AHIS307
BHIS307

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLN100
APHE283
BGLN100
BPHE283

226707

PDB entries from 2024-10-30

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