4O7X
Crystal structure of human ALKBH5 in complex with Mn2+
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 301 |
| Chain | Residue |
| A | HIS204 |
| A | ASP206 |
| A | HIS266 |
| A | HOH401 |
| A | HOH474 |
| A | HOH475 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"35333330","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24778178","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35333330","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WKV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24616105","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24778178","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35333330","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7V4G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WKV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WL0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by MAPK8 and MAPK9","evidences":[{"source":"PubMed","id":"34048572","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"37369679","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"34048572","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
