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4O7E

Crystal structure of the first bromodomain of human BRD4 in complex with SB-610251-B

Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 2RN A 201
ChainResidue
AVAL87
ALEU92
AHOH304
AHOH308
AHOH340
AHOH367
B2RN201

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 202
ChainResidue
ALYS102
ATHR103
AASN135
AILE100
AILE101

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 2RN A 203
ChainResidue
AGLN78
APHE79
AASP145
ALEU148
AMET149
AHOH331
BTRP81
BLYS91
BLEU92
BASP145
B2RN202

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 2RN B 201
ChainResidue
ATRP81
ALYS91
ALEU92
A2RN201
BGLN78
BPHE79
BTRP81
BASP145
BMET149
BHOH391

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 2RN B 202
ChainResidue
A2RN203
BPRO82
BGLN85
BLEU92
BHOH303
BHOH306
BHOH371

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 203
ChainResidue
BILE100
BILE101
BLYS102
BTHR103
BASN135

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO B 204
ChainResidue
BTRP75
BHIS77
BGLN78
BALA80
BTRP81
BGLN84

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140
BASN140

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99
BLYS99

219140

PDB entries from 2024-05-01

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