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4O7C

Crystal structure of the first bromodomain of human BRD4 in complex with SB-614067-R

Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 2RK A 201
ChainResidue
ATRP81
AILE146
AHOH301
AHOH308
AHOH328
AHOH347
AHOH369
APRO82
AGLN85
AVAL87
ALEU92
AASP96
ALYS99
ATYR139
AASN140

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 202
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

227111

PDB entries from 2024-11-06

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