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4O78

Crystal structure of the first bromodomain of human BRD4 in complex with GW612286X

Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE SAV A 201
ChainResidue
ATRP81
AHOH304
AHOH312
AHOH340
AHOH422
AHOH459
APRO82
APHE83
AGLN85
ALEU92
AASP96
ALYS99
ATYR139
AILE146

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 202
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH420

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 203
ChainResidue
APRO86
AGLY108
ATHR109
ALYS112
AHOH505
AHOH525

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 204
ChainResidue
ALYS57
AGLN59
AASN117

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 205
ChainResidue
ATYR137
AASN140
APRO142
AHOH329
AHOH344
AHOH484

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 206
ChainResidue
ATRP81
APRO95
AASP96
ATYR139

site_idAC7
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PGE A 207
ChainResidue
ALYS91
ALEU92
AASP96
AILE100
AILE138
ATYR139
AHOH340
AHOH399
AHOH473

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CL A 208
ChainResidue
APRO48
APRO104
AMET105
AASP106
AHOH319
AHOH341

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues106
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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