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4O77

Crystal structure of the first bromodomain of human BRD4 in complex with SB 202190

Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 2RE A 201
ChainResidue
ATRP81
AHOH317
BPHE79
BTRP81
BASP145
BLEU148
BMET149
APRO82
AVAL87
ATYR97
AASN135
ACYS136
AASN140
AHOH304
AHOH305

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 2RE B 201
ChainResidue
APHE79
AASP145
ALEU148
AHOH340
BTRP81
BTYR97
BASN135
BCYS136
BASN140
BHOH308
BHOH328
BHOH394

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues212
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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