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4O71

Crystal structure of the first bromodomain of human BRD4 in complex with FLAVOPIRIDOL

Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE CPB A 201
ChainResidue
ATRP81
AHOH402
AHOH405
AHOH468
AHOH469
BPHE79
BLEU148
BMET149
APRO82
AVAL87
ALEU92
ALEU94
AASN140
AHOH302
AHOH315
AHOH373

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 202
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH487

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE EDO A 203
ChainResidue
AASN130
AHOH445

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 204
ChainResidue
ATRP75
AGLN84
AGLY108
ALYS111
AHOH344
AHOH414
BLYS141

site_idAC5
Number of Residues14
DetailsBINDING SITE FOR RESIDUE CPB B 201
ChainResidue
APHE79
ALEU148
AMET149
AHOH314
BTRP81
BPRO82
BVAL87
BLEU92
BASN140
BHOH303
BHOH327
BHOH330
BHOH336
BHOH426

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO B 202
ChainResidue
AASN116
AHOH413
BILE100
BILE101
BLYS102
BTHR103
BASN135
BHOH357

site_idAC7
Number of Residues9
DetailsBINDING SITE FOR RESIDUE EDO B 203
ChainResidue
ALYS72
ALYS111
AGLU115
BTYR137
BASN140
BLYS141
BPRO142
BGLU151
BHOH337

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140
BASN140

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99
BLYS99

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PDB entries from 2024-07-24

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