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4O70

Crystal structure of the first bromodomain of human BRD4 in complex with DINACICLIB

Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 1QK A 201
ChainResidue
ATRP81
BHIS77
BGLN78
APHE83
ALEU92
AASN140
AASP144
AASP145
AILE146
AHOH329
AHOH378

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 1QK A 202
ChainResidue
AVAL90
ALYS91
AASN93
ALYS155
ALEU156
AGLN159
AHOH356
AHOH377
BTRP81
B1QK201
BHOH386

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 203
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH422

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 204
ChainResidue
ALYS72
ATYR137
AVAL147
AGLU151
AHOH312

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 205
ChainResidue
ALEU67
ATYR137
AHOH309

site_idAC6
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 1QK B 201
ChainResidue
A1QK202
BTRP81
BPRO82
BPHE83
BVAL87
BLEU92
BASN140
BASP144
BASP145
BILE146
BHOH405

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 202
ChainResidue
BILE100
BILE101
BLYS102
BTHR103
BASN135

site_idAC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO B 203
ChainResidue
BARG58
BTHR60
BGLN62
BLEU63
BTRP120
BALA122
BHOH355

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO B 204
ChainResidue
BSER42
BMET43
BVAL90
BLEU158
BILE161
BASN162

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140
BASN140

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99
BLYS99

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PDB entries from 2024-11-06

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