4O5Q
Crystal Structure of the Alkylhydroperoxide Reductase AhpF from Escherichia coli
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000302 | biological_process | response to reactive oxygen species |
A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
A | 0005829 | cellular_component | cytosol |
A | 0006979 | biological_process | response to oxidative stress |
A | 0008785 | molecular_function | alkyl hydroperoxide reductase activity |
A | 0009321 | cellular_component | alkyl hydroperoxide reductase complex |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
A | 0042744 | biological_process | hydrogen peroxide catabolic process |
A | 0045454 | biological_process | cell redox homeostasis |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0051287 | molecular_function | NAD binding |
A | 0071949 | molecular_function | FAD binding |
A | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 37 |
Details | BINDING SITE FOR RESIDUE FAD A 601 |
Chain | Residue |
A | GLY219 |
A | THR252 |
A | ASN257 |
A | GLN288 |
A | SER289 |
A | ALA290 |
A | ALA321 |
A | THR322 |
A | GLY323 |
A | CYS348 |
A | ASN454 |
A | GLY221 |
A | TRP457 |
A | GLY487 |
A | ASP488 |
A | LYS495 |
A | GLN496 |
A | ILE497 |
A | ALA500 |
A | GOL619 |
A | HOH701 |
A | HOH702 |
A | PRO222 |
A | HOH736 |
A | HOH738 |
A | HOH739 |
A | HOH747 |
A | HOH748 |
A | HOH753 |
A | HOH814 |
A | HOH834 |
A | ALA223 |
A | GLY242 |
A | GLU243 |
A | ARG244 |
A | GLY247 |
A | GLN248 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 A 602 |
Chain | Residue |
A | ALA105 |
A | GLN106 |
A | SER107 |
A | SER126 |
A | SER128 |
A | HOH930 |
A | HOH1084 |
A | HOH1085 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 603 |
Chain | Residue |
A | GLY364 |
A | ASN365 |
A | SER366 |
A | PGE621 |
A | HOH785 |
site_id | AC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SO4 A 604 |
Chain | Residue |
A | PRO453 |
A | ASN454 |
A | THR455 |
A | ASN456 |
A | TRP457 |
A | HOH774 |
A | HOH834 |
A | HOH918 |
A | HOH1117 |
site_id | AC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 A 605 |
Chain | Residue |
A | PRO332 |
A | GLY333 |
A | GLU334 |
A | ASP335 |
A | GLN336 |
A | HOH865 |
A | HOH902 |
A | HOH903 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 606 |
Chain | Residue |
A | ARG357 |
A | HIS380 |
A | HOH789 |
A | HOH1141 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 607 |
Chain | Residue |
A | HIS438 |
A | ASN439 |
A | HOH802 |
A | HOH842 |
A | HOH1022 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 608 |
Chain | Residue |
A | SER30 |
A | ALA31 |
A | HOH812 |
A | HOH958 |
A | HOH1178 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 609 |
Chain | Residue |
A | ASP473 |
A | ALA474 |
A | HOH1064 |
A | HOH1105 |
A | HOH1105 |
site_id | BC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PGE A 610 |
Chain | Residue |
A | ASN439 |
A | GLU459 |
A | GLY460 |
A | ALA461 |
A | GLU463 |
A | ASN479 |
A | HOH915 |
A | HOH1022 |
site_id | BC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PGE A 611 |
Chain | Residue |
A | HOH1131 |
A | HOH1138 |
A | ILE471 |
A | GLU477 |
A | THR478 |
A | ASN479 |
A | HOH922 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PGE A 612 |
Chain | Residue |
A | ILE236 |
A | ILE372 |
A | LYS519 |
A | HOH1101 |
site_id | BC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 613 |
Chain | Residue |
A | HIS100 |
A | PRO101 |
A | SER102 |
A | GLN106 |
A | ASN131 |
A | LEU145 |
A | HOH1100 |
A | HOH1114 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CD A 614 |
Chain | Residue |
A | HIS85 |
A | GLU110 |
A | HIS114 |
A | HIS130 |
A | HOH1046 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 615 |
Chain | Residue |
A | ARG233 |
A | GLY235 |
A | LYS354 |
A | HOH1191 |
site_id | BC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PGE A 616 |
Chain | Residue |
A | GLU477 |
A | THR478 |
A | ASN479 |
A | LYS481 |
A | GOL625 |
A | HOH921 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 A 617 |
Chain | Residue |
A | PHE245 |
A | LYS274 |
A | HOH813 |
A | HOH1017 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PGE A 618 |
Chain | Residue |
A | GLU104 |
A | GLY156 |
A | GLN160 |
A | MET169 |
A | HOH930 |
A | HOH1086 |
site_id | CC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE GOL A 619 |
Chain | Residue |
A | THR252 |
A | VAL253 |
A | ASP254 |
A | THR339 |
A | ASP349 |
A | FAD601 |
A | HOH702 |
A | HOH703 |
A | HOH815 |
A | HOH1183 |
site_id | CC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE TRS A 620 |
Chain | Residue |
A | GLU416 |
A | ASN465 |
A | ARG466 |
A | HOH714 |
A | HOH923 |
A | HOH1147 |
site_id | CC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PGE A 621 |
Chain | Residue |
A | ARG327 |
A | SER366 |
A | VAL447 |
A | GLN448 |
A | ILE449 |
A | GLY450 |
A | LEU451 |
A | SO4603 |
site_id | CC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 622 |
Chain | Residue |
A | GLY341 |
A | PHE353 |
A | HOH706 |
A | HOH1182 |
site_id | CC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 623 |
Chain | Residue |
A | ASP335 |
A | GLN336 |
A | ARG338 |
A | LYS340 |
A | LYS391 |
A | HOH1119 |
site_id | CC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 624 |
Chain | Residue |
A | ASP28 |
A | ALA34 |
A | LYS37 |
A | GLU54 |
A | GLY300 |
A | ARG316 |
A | THR518 |
A | ALA521 |
site_id | CC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 625 |
Chain | Residue |
A | GLU299 |
A | LYS481 |
A | ARG517 |
A | THR518 |
A | PGE616 |
A | HOH837 |
A | HOH1129 |
Functional Information from PROSITE/UniProt
site_id | PS00573 |
Number of Residues | 21 |
Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CphCDGpl..FkgkrVaVIGGGN |
Chain | Residue | Details |
A | CYS345-ASN365 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ASP214 | |
A | ARG357 | |
A | THR478 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
Chain | Residue | Details |
A | LYS53 | |
A | LYS354 |