4O5Q
Crystal Structure of the Alkylhydroperoxide Reductase AhpF from Escherichia coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000302 | biological_process | response to reactive oxygen species |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008785 | molecular_function | alkyl hydroperoxide reductase activity |
| A | 0009321 | cellular_component | alkyl hydroperoxide reductase complex |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0071949 | molecular_function | FAD binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD A 601 |
| Chain | Residue |
| A | GLY219 |
| A | THR252 |
| A | ASN257 |
| A | GLN288 |
| A | SER289 |
| A | ALA290 |
| A | ALA321 |
| A | THR322 |
| A | GLY323 |
| A | CYS348 |
| A | ASN454 |
| A | GLY221 |
| A | TRP457 |
| A | GLY487 |
| A | ASP488 |
| A | LYS495 |
| A | GLN496 |
| A | ILE497 |
| A | ALA500 |
| A | GOL619 |
| A | HOH701 |
| A | HOH702 |
| A | PRO222 |
| A | HOH736 |
| A | HOH738 |
| A | HOH739 |
| A | HOH747 |
| A | HOH748 |
| A | HOH753 |
| A | HOH814 |
| A | HOH834 |
| A | ALA223 |
| A | GLY242 |
| A | GLU243 |
| A | ARG244 |
| A | GLY247 |
| A | GLN248 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 602 |
| Chain | Residue |
| A | ALA105 |
| A | GLN106 |
| A | SER107 |
| A | SER126 |
| A | SER128 |
| A | HOH930 |
| A | HOH1084 |
| A | HOH1085 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 603 |
| Chain | Residue |
| A | GLY364 |
| A | ASN365 |
| A | SER366 |
| A | PGE621 |
| A | HOH785 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 604 |
| Chain | Residue |
| A | PRO453 |
| A | ASN454 |
| A | THR455 |
| A | ASN456 |
| A | TRP457 |
| A | HOH774 |
| A | HOH834 |
| A | HOH918 |
| A | HOH1117 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 605 |
| Chain | Residue |
| A | PRO332 |
| A | GLY333 |
| A | GLU334 |
| A | ASP335 |
| A | GLN336 |
| A | HOH865 |
| A | HOH902 |
| A | HOH903 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 606 |
| Chain | Residue |
| A | ARG357 |
| A | HIS380 |
| A | HOH789 |
| A | HOH1141 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 607 |
| Chain | Residue |
| A | HIS438 |
| A | ASN439 |
| A | HOH802 |
| A | HOH842 |
| A | HOH1022 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 608 |
| Chain | Residue |
| A | SER30 |
| A | ALA31 |
| A | HOH812 |
| A | HOH958 |
| A | HOH1178 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 609 |
| Chain | Residue |
| A | ASP473 |
| A | ALA474 |
| A | HOH1064 |
| A | HOH1105 |
| A | HOH1105 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGE A 610 |
| Chain | Residue |
| A | ASN439 |
| A | GLU459 |
| A | GLY460 |
| A | ALA461 |
| A | GLU463 |
| A | ASN479 |
| A | HOH915 |
| A | HOH1022 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE A 611 |
| Chain | Residue |
| A | HOH1131 |
| A | HOH1138 |
| A | ILE471 |
| A | GLU477 |
| A | THR478 |
| A | ASN479 |
| A | HOH922 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE A 612 |
| Chain | Residue |
| A | ILE236 |
| A | ILE372 |
| A | LYS519 |
| A | HOH1101 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 613 |
| Chain | Residue |
| A | HIS100 |
| A | PRO101 |
| A | SER102 |
| A | GLN106 |
| A | ASN131 |
| A | LEU145 |
| A | HOH1100 |
| A | HOH1114 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CD A 614 |
| Chain | Residue |
| A | HIS85 |
| A | GLU110 |
| A | HIS114 |
| A | HIS130 |
| A | HOH1046 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 615 |
| Chain | Residue |
| A | ARG233 |
| A | GLY235 |
| A | LYS354 |
| A | HOH1191 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE A 616 |
| Chain | Residue |
| A | GLU477 |
| A | THR478 |
| A | ASN479 |
| A | LYS481 |
| A | GOL625 |
| A | HOH921 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 A 617 |
| Chain | Residue |
| A | PHE245 |
| A | LYS274 |
| A | HOH813 |
| A | HOH1017 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE A 618 |
| Chain | Residue |
| A | GLU104 |
| A | GLY156 |
| A | GLN160 |
| A | MET169 |
| A | HOH930 |
| A | HOH1086 |
| site_id | CC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 619 |
| Chain | Residue |
| A | THR252 |
| A | VAL253 |
| A | ASP254 |
| A | THR339 |
| A | ASP349 |
| A | FAD601 |
| A | HOH702 |
| A | HOH703 |
| A | HOH815 |
| A | HOH1183 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TRS A 620 |
| Chain | Residue |
| A | GLU416 |
| A | ASN465 |
| A | ARG466 |
| A | HOH714 |
| A | HOH923 |
| A | HOH1147 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGE A 621 |
| Chain | Residue |
| A | ARG327 |
| A | SER366 |
| A | VAL447 |
| A | GLN448 |
| A | ILE449 |
| A | GLY450 |
| A | LEU451 |
| A | SO4603 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 622 |
| Chain | Residue |
| A | GLY341 |
| A | PHE353 |
| A | HOH706 |
| A | HOH1182 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 623 |
| Chain | Residue |
| A | ASP335 |
| A | GLN336 |
| A | ARG338 |
| A | LYS340 |
| A | LYS391 |
| A | HOH1119 |
| site_id | CC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 624 |
| Chain | Residue |
| A | ASP28 |
| A | ALA34 |
| A | LYS37 |
| A | GLU54 |
| A | GLY300 |
| A | ARG316 |
| A | THR518 |
| A | ALA521 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 625 |
| Chain | Residue |
| A | GLU299 |
| A | LYS481 |
| A | ARG517 |
| A | THR518 |
| A | PGE616 |
| A | HOH837 |
| A | HOH1129 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 21 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CphCDGpl..FkgkrVaVIGGGN |
| Chain | Residue | Details |
| A | CYS345-ASN365 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP214 | |
| A | ARG357 | |
| A | THR478 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
| Chain | Residue | Details |
| A | LYS53 | |
| A | LYS354 |
