4O4F

Crystal Structure of an Inositol hexakisphosphate kinase EhIP6KA in complexed with ATP and InsP6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000828	molecular_function	inositol hexakisphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0032958	biological_process	inositol phosphate biosynthetic process
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 401

Chain	Residue
A	GLY23
A	MG402
A	IHP403
A	ATP404
A	HOH641
A	HOH644
A	HOH645

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 402

Chain	Residue
A	ATP404
A	HOH628
A	HOH641
A	HOH644
A	HOH678
A	ASP231
A	MG401

---

site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE IHP A 403

Chain	Residue
A	GLY23
A	GLN27
A	LYS101
A	LYS115
A	LYS118
A	ARG119
A	ARG152
A	TYR153
A	GLU242
A	MG401
A	ATP404
A	HOH620
A	HOH625
A	HOH628
A	HOH641
A	HOH644
A	HOH645
A	HOH650
A	HOH667
A	HOH681

---

site_id	AC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ATP A 404

Chain	Residue
A	GLY23
A	SER24
A	PHE25
A	GLN27
A	LEU36
A	LYS38
A	PHE77
A	MET85
A	GLU86
A	ASN87
A	LEU88
A	ASP99
A	ASP231
A	MG401
A	MG402
A	IHP403
A	HOH616
A	HOH624
A	HOH638
A	HOH641
A	HOH643
A	HOH644

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PO4 A 405

Chain	Residue
A	HIS73
A	HIS73
A	HIS73
A	HIS73
A	HOH653
A	HOH653
A	HOH653
A	HOH653
A	HOH664
A	HOH664
A	HOH664
A	HOH664

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PO4 A 406

Chain	Residue
A	MET198
A	ARG201
A	ASP247
A	GLY248
A	PHE249
A	LEU250
A	HOH579
A	HOH583
A	HOH629
A	HOH630
A	HOH651

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