4O3C

Crystal structure of the GLUA2 ligand-binding domain in complex with L-aspartate at 1.50 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ASP A 301

Chain	Residue
A	TYR61
A	HOH420
A	HOH465
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 302

Chain	Residue
A	SER108
A	ACT304

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 303

Chain	Residue
A	ARG31
A	HIS46
A	LYS240
A	GLN244
A	SO4306
A	HOH607
A	HOH609

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 304

Chain	Residue
A	MET107
A	SER108
A	SER217
A	ASN242
A	CL302
A	LI305
A	HOH498

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LI A 305

Chain	Residue
A	SER217
A	ASN242
A	ACT304
A	HOH412
A	HOH509

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 306

Chain	Residue
A	HIS23
A	GLU24
A	ARG31
A	HIS46
A	LYS240
A	GOL303
A	HOH591

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 307

Chain	Residue
A	SER140
A	LYS144
A	ARG148
A	HOH440
A	HOH462
A	HOH497
A	HOH615

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 308

Chain	Residue
A	GLU27
A	GLY28
A	ASN29
A	GLU30
A	ARG149
A	LYS151
A	HOH559

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 309

Chain	Residue
A	ARG148
A	TRP159
A	ARG163
A	HOH551

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3

---