4O3B

Crystal structure of an open/closed glua2 ligand-binding domain dimer at 1.91 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 301

Chain	Residue
A	ARG148
A	ARG163
A	HOH496
B	HIS23

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	HIS46
A	ARG172
A	GLU176
A	LYS240
A	GLN244

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	SER217
A	HOH639
B	MET107
B	SER108
B	GOL304
B	HOH565

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 304

Chain	Residue
A	LYS116
A	LYS185
A	HOH429
B	ILE70
B	HOH604

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GOL A 305

Chain	Residue
A	PRO105
A	PHE106
A	MET107
A	SER108
A	ASN242
A	HOH459
A	HOH499
A	HOH614
A	HOH636
B	SER217
B	LYS218
B	GLY219

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 306

Chain	Residue
A	VAL99
A	LYS226
A	HOH451
B	GLY118
B	THR119
B	HOH503

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 307

Chain	Residue
A	LYS117

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PEG A 308

Chain	Residue
A	SER108
A	LEU109
A	SER194
A	THR195
A	GLU198
A	ASN214
A	SER217
A	HOH454
A	HOH575

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 309

Chain	Residue
A	TYR61
A	ARG96
A	SER142
A	HOH470
A	HOH649
A	HOH650

---

site_id	BC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU B 301

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	HOH403
B	HOH432
B	HOH502

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	SER140
B	LYS144
B	ARG148
B	HOH413
B	HOH440
B	HOH469
B	HOH589

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 303

Chain	Residue
B	LYS116
B	LYS185
B	HOH438

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 304

Chain	Residue
A	SER217
A	LYS218
A	SO4303
A	HOH575
B	PRO105
B	SER108
B	ASN242
B	HOH588
B	HOH663

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 305

Chain	Residue
A	ASN214
A	ASP216
A	SER217
B	ASP248
B	ASN252

---

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PG4 B 306

Chain	Residue
A	GLU24
B	LYS144
B	ARG148
B	TRP159
B	ARG163
B	PHE170
B	HOH608

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---