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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4O3A

Crystal structure of the glua2 ligand-binding domain in complex with L-aspartate at 1.80 a resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 301

Chain	Residue
A	ASN29
A	LYS50
A	TYR51
A	HOH432
A	HOH495

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ASP A 302

Chain	Residue
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193
A	HOH410
A	HOH478
A	TYR61
A	PRO89
A	LEU90
A	THR91

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 303

Chain	Residue
A	HIS23
A	GLU30
A	ACT308
C	HIS23

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 304

Chain	Residue
A	GLU42
A	HIS46
A	LEU241
A	HOH635
B	GLU166

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN A 305

Chain	Residue
A	ASP156

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 306

Chain	Residue
A	PHE106
A	SER108
A	SER217
A	ASN242
A	HOH621

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 307

Chain	Residue
A	ARG180
A	SER184
A	LYS187
A	TYR188

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 308

Chain	Residue
A	LYS20
A	HIS23
A	GLU30
A	ZN303
C	HIS23
C	GLU24

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 309

Chain	Residue
A	LYS116
A	LYS185
A	HOH632

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 310

Chain	Residue
A	ASN214
A	ASP216
A	SER217
A	ASP248

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 311

Chain	Residue
A	ARG64
A	TRP71
A	VAL99
A	GLY118
A	PRO120
A	HOH449
A	HOH465

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 312

Chain	Residue
A	GLU201
A	LYS210

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 313

Chain	Residue
A	LYS144
A	ARG148
A	PHE170
A	HOH634

site_id	BC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ASP B 301

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143
B	GLU193
B	MET196
B	HOH416
B	HOH575
B	HOH583

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 302

Chain	Residue
B	HIS23
C	ASP65
C	ASP67
C	ACT309
C	HOH559

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 303

Chain	Residue
A	GLU166
B	GLU42
B	HIS46
B	HOH573

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT B 304

Chain	Residue
B	ARG180
B	SER184
B	LYS187

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 305

Chain	Residue
B	LYS69
B	TYR80
B	GLY118
B	LYS185
B	HOH460
B	HOH555

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 306

Chain	Residue
B	ILE70
B	TYR80
B	LYS116
B	LYS185
B	HOH460

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL B 307

Chain	Residue
B	LYS210
B	GLU201

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 308

Chain	Residue
B	ASP248
C	ASP216
C	SER217

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG B 309

Chain	Residue
B	HIS46
B	LEU236
B	LYS240
B	HOH445
C	GLU98

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG B 310

Chain	Residue
B	ARG64
B	TRP71
B	GLY118
B	HOH496
B	HOH520
B	HOH593

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG B 311

Chain	Residue
B	ASN232
B	LEU236
B	HOH444
C	GLU97
C	GLU98
C	LYS226

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 312

Chain	Residue
B	LYS4
B	GLY262
B	SER263

site_id	CC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ASP C 301

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	GLY141
C	SER142
C	THR143
C	GLU193
C	HOH403
C	HOH444

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C 302

Chain	Residue
C	GLU42
C	LYS45
C	HIS46

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 303

Chain	Residue
B	GLU24
C	ASP139
C	SER140
C	ACT307
C	HOH553

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 304

Chain	Residue
C	HIS46
C	LYS240
C	HOH480
C	HOH552

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN C 305

Chain	Residue
C	ASP156
C	HOH560

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 306

Chain	Residue
B	SER217
B	HOH465
B	HOH579
C	PRO105
C	SER108

site_id	DC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT C 307

Chain	Residue
B	GLU24
C	ALA63
C	ARG64
C	ASN72
C	ASP139
C	SER140
C	ZN303
C	HOH528

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 308

Chain	Residue
B	ASN214
B	ASP216
B	SER217
C	ASP248
C	HOH557

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 309

Chain	Residue
B	MET19
B	HIS23
B	ZN302
C	ASP65
C	ASP67

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT C 310

Chain	Residue
C	ARG180
C	LYS187
C	TYR188

site_id	DC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT C 311

Chain	Residue
B	LYS151
C	LYS20
C	GLU30

site_id	EC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 312

Chain	Residue
B	PRO105
B	SER108
B	ASN242
B	HOH406
C	SER217
C	HOH514

site_id	EC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL C 313

Chain	Residue
B	GLU27
C	ASP139
C	SER168
C	PHE170
C	VAL171
C	ARG172
C	HOH476
C	HOH511
C	HOH576

site_id	EC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEG C 314

Chain	Residue
C	ARG64
C	TRP71
C	VAL99
C	GLY118
C	HOH472
C	HOH495
C	HOH506

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	9
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

246333

PDB entries from 2025-12-17

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