Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4O2R

Structure of Mus musculus Rheb G63V mutant bound to GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0005681	cellular_component	spliceosomal complex
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0009615	biological_process	response to virus
A	0012505	cellular_component	endomembrane system
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0019901	molecular_function	protein kinase binding
A	0030295	molecular_function	protein kinase activator activity
A	0031669	biological_process	cellular response to nutrient levels
A	0032006	biological_process	regulation of TOR signaling
A	0032008	biological_process	positive regulation of TOR signaling
A	0043539	molecular_function	protein serine/threonine kinase activator activity
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0048709	biological_process	oligodendrocyte differentiation
A	0048714	biological_process	positive regulation of oligodendrocyte differentiation
A	0120163	biological_process	negative regulation of cold-induced thermogenesis
A	1904263	biological_process	positive regulation of TORC1 signaling
A	2000074	biological_process	regulation of type B pancreatic cell development
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0005681	cellular_component	spliceosomal complex
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007264	biological_process	small GTPase-mediated signal transduction
B	0009615	biological_process	response to virus
B	0012505	cellular_component	endomembrane system
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0019003	molecular_function	GDP binding
B	0019901	molecular_function	protein kinase binding
B	0030295	molecular_function	protein kinase activator activity
B	0031669	biological_process	cellular response to nutrient levels
B	0032006	biological_process	regulation of TOR signaling
B	0032008	biological_process	positive regulation of TOR signaling
B	0043539	molecular_function	protein serine/threonine kinase activator activity
B	0045202	cellular_component	synapse
B	0046872	molecular_function	metal ion binding
B	0048709	biological_process	oligodendrocyte differentiation
B	0048714	biological_process	positive regulation of oligodendrocyte differentiation
B	0120163	biological_process	negative regulation of cold-induced thermogenesis
B	1904263	biological_process	positive regulation of TORC1 signaling
B	2000074	biological_process	regulation of type B pancreatic cell development

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GDP A 201

Chain	Residue
A	SER16
A	ASN119
A	LYS120
A	ASP122
A	LEU123
A	SER149
A	ALA150
A	LYS151
A	MG202
A	HOH321
A	HOH325
A	VAL17
A	HOH377
A	GLY18
A	LYS19
A	SER20
A	SER21
A	PHE31
A	VAL32
A	ASP33

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 202

Chain	Residue
A	LYS19
A	SER20
A	ASP60
A	THR61
A	GDP201
A	HOH302
A	HOH325

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GDP B 201

Chain	Residue
B	SER16
B	VAL17
B	GLY18
B	LYS19
B	SER20
B	SER21
B	PHE31
B	VAL32
B	ASP33
B	ASN119
B	LYS120
B	ASP122
B	LEU123
B	SER149
B	ALA150
B	LYS151
B	MG202
B	HOH301
B	HOH328

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG B 202

Chain	Residue
B	LYS19
B	SER20
B	THR38
B	ASP60
B	THR61
B	GDP201
B	HOH301

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Motif: {"description":"Effector region"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24648513","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4O25","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O2L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24648513","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q15382","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24648513","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4O25","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Important for autoinhibition of GTPase activity","evidences":[{"source":"UniProtKB","id":"Q15382","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by MAPKAPK5","evidences":[{"source":"PubMed","id":"21336308","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q15382","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)