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4O2R

Structure of Mus musculus Rheb G63V mutant bound to GDP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0005681cellular_componentspliceosomal complex
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007264biological_processsmall GTPase-mediated signal transduction
A0009615biological_processresponse to virus
A0012505cellular_componentendomembrane system
A0014069cellular_componentpostsynaptic density
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0019901molecular_functionprotein kinase binding
A0030295molecular_functionprotein kinase activator activity
A0031669biological_processcellular response to nutrient levels
A0032006biological_processregulation of TOR signaling
A0032008biological_processpositive regulation of TOR signaling
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0048709biological_processoligodendrocyte differentiation
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0120163biological_processnegative regulation of cold-induced thermogenesis
A1904263biological_processpositive regulation of TORC1 signaling
A2000074biological_processregulation of type B pancreatic cell development
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0003924molecular_functionGTPase activity
B0005525molecular_functionGTP binding
B0005681cellular_componentspliceosomal complex
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007264biological_processsmall GTPase-mediated signal transduction
B0009615biological_processresponse to virus
B0012505cellular_componentendomembrane system
B0014069cellular_componentpostsynaptic density
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0019901molecular_functionprotein kinase binding
B0030295molecular_functionprotein kinase activator activity
B0031669biological_processcellular response to nutrient levels
B0032006biological_processregulation of TOR signaling
B0032008biological_processpositive regulation of TOR signaling
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0045202cellular_componentsynapse
B0046872molecular_functionmetal ion binding
B0048709biological_processoligodendrocyte differentiation
B0048714biological_processpositive regulation of oligodendrocyte differentiation
B0120163biological_processnegative regulation of cold-induced thermogenesis
B1904263biological_processpositive regulation of TORC1 signaling
B2000074biological_processregulation of type B pancreatic cell development
Functional Information from PDB Data
site_idAC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE GDP A 201
ChainResidue
ASER16
AASN119
ALYS120
AASP122
ALEU123
ASER149
AALA150
ALYS151
AMG202
AHOH321
AHOH325
AVAL17
AHOH377
AGLY18
ALYS19
ASER20
ASER21
APHE31
AVAL32
AASP33

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 202
ChainResidue
ALYS19
ASER20
AASP60
ATHR61
AGDP201
AHOH302
AHOH325

site_idAC3
Number of Residues19
DetailsBINDING SITE FOR RESIDUE GDP B 201
ChainResidue
BSER16
BVAL17
BGLY18
BLYS19
BSER20
BSER21
BPHE31
BVAL32
BASP33
BASN119
BLYS120
BASP122
BLEU123
BSER149
BALA150
BLYS151
BMG202
BHOH301
BHOH328

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG B 202
ChainResidue
BLYS19
BSER20
BTHR38
BASP60
BTHR61
BGDP201
BHOH301

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:24648513, ECO:0007744|PDB:4O25, ECO:0007744|PDB:4O2L
ChainResidueDetails
ASER16
AASN119
AASP122
AALA150
BSER16
BVAL17
BGLY18
BLYS19
BSER21
BVAL32
BASP33
AVAL17
BTYR35
BPRO37
BASN119
BASP122
BALA150
AGLY18
ALYS19
ASER21
AVAL32
AASP33
ATYR35
APRO37

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:24648513
ChainResidueDetails
ASER20
BSER20

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q15382
ChainResidueDetails
ATHR38
BTHR38

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:24648513, ECO:0007744|PDB:4O25
ChainResidueDetails
AVAL63
ALYS120
BVAL63
BLYS120

site_idSWS_FT_FI5
Number of Residues2
DetailsSITE: Important for autoinhibition of GTPase activity => ECO:0000250|UniProtKB:Q15382
ChainResidueDetails
ATYR35
BTYR35

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPKAPK5 => ECO:0000269|PubMed:21336308
ChainResidueDetails
ASER130
BSER130

site_idSWS_FT_FI7
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q15382
ChainResidueDetails
ALYS8
BLYS8

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PDB entries from 2025-06-11

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