Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4O17

Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0007165biological_processsignal transduction
A0007267biological_processcell-cell signaling
A0007623biological_processcircadian rhythm
A0008284biological_processpositive regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0009435biological_processNAD biosynthetic process
A0016607cellular_componentnuclear speck
A0016740molecular_functiontransferase activity
A0016757molecular_functionglycosyltransferase activity
A0019363biological_processpyridine nucleotide biosynthetic process
A0030054cellular_componentcell junction
A0032922biological_processcircadian regulation of gene expression
A0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
A0042802molecular_functionidentical protein binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0047280molecular_functionnicotinamide phosphoribosyltransferase activity
A0048511biological_processrhythmic process
A0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
A0060612biological_processadipose tissue development
A0070062cellular_componentextracellular exosome
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0007165biological_processsignal transduction
B0007267biological_processcell-cell signaling
B0007623biological_processcircadian rhythm
B0008284biological_processpositive regulation of cell population proliferation
B0008286biological_processinsulin receptor signaling pathway
B0009435biological_processNAD biosynthetic process
B0016607cellular_componentnuclear speck
B0016740molecular_functiontransferase activity
B0016757molecular_functionglycosyltransferase activity
B0019363biological_processpyridine nucleotide biosynthetic process
B0030054cellular_componentcell junction
B0032922biological_processcircadian regulation of gene expression
B0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
B0042802molecular_functionidentical protein binding
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0047280molecular_functionnicotinamide phosphoribosyltransferase activity
B0048511biological_processrhythmic process
B0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
B0060612biological_processadipose tissue development
B0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PO4 A 601
ChainResidue
AARG392
ASER398
ALYS400
AHOH742
AHOH904
AHOH952
AHOH961
AHOH987

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE EDO A 602
ChainResidue
ACYS401
APHE414
ALYS415
ASER425
BHIS247
BSER248
BTHR251
BHOH769
ALYS400

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 603
ChainResidue
AGLY197
ASER199
AGLN388
AHOH950
BLEU390
BHOH925

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO A 604
ChainResidue
AASP313
AGLY353
AASP354
AEDO605
AHOH953
BLYS423
BPO4601
BHOH975

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 605
ChainResidue
AGLU246
AHIS247
AARG311
AEDO604

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 606
ChainResidue
APHE193
AVAL242
ASER275
AHOH767

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 607
ChainResidue
AASP192
AGLY194
ATYR195
AVAL198
AGLY207
AALA208
ATHR220

site_idAC8
Number of Residues11
DetailsBINDING SITE FOR RESIDUE PO4 B 601
ChainResidue
AEDO604
BARG40
BARG392
BSER398
BLYS400
BHOH760
BHOH793
BHOH892
BHOH923
BHOH975
BHOH1026

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO B 602
ChainResidue
ATRP156
ALEU390
BGLY197
BVAL198
BSER199
BHOH925

site_idBC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE EDO B 603
ChainResidue
AHIS247
ASER248
ATHR251
AHOH745
BLYS400
BCYS401
BPHE414
BLYS415
BSER425

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBINDING:
ChainResidueDetails
AARG196
BHIS247
BARG311
BGLY353
BGLY384
BARG392
AASP219
AHIS247
AARG311
AGLY353
AGLY384
AARG392
BARG196
BASP219

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895
ChainResidueDetails
AMET1
BMET1

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR188
BTYR188

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER472
BSER472

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon