4NZY
Crystal structure (type-2) of dTMP kinase (st1543) from Sulfolobus Tokodaii Strain7
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004798 | molecular_function | thymidylate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006227 | biological_process | dUDP biosynthetic process |
| A | 0006233 | biological_process | dTDP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004798 | molecular_function | thymidylate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006227 | biological_process | dUDP biosynthetic process |
| B | 0006233 | biological_process | dTDP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016310 | biological_process | phosphorylation |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details |
| Chain | Residue |
| A | TYR35 |
| A | THR37 |
| A | SER41 |
| A | SER42 |
| A | ASP43 |
| A | ARG74 |
| A | TYR78 |
| A | HOH473 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details |
| Chain | Residue |
| A | SER15 |
| A | GLY16 |
| A | LYS17 |
| A | SER18 |
| A | HOH446 |
| A | GLY14 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details |
| Chain | Residue |
| A | VAL107 |
| A | ASP108 |
| A | TRP111 |
| A | HOH461 |
| A | HOH501 |
| B | SER117 |
| B | PHE118 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details |
| Chain | Residue |
| A | TRP39 |
| A | SER42 |
| A | HIS67 |
| A | ASP70 |
| A | ARG74 |
| A | HOH429 |
| A | HOH488 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details |
| Chain | Residue |
| A | LYS195 |
| A | ARG202 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details |
| Chain | Residue |
| A | SER103 |
| A | LEU171 |
| A | GLU174 |
| A | VAL175 |
| A | LYS178 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details |
| Chain | Residue |
| A | TYR96 |
| A | PRO122 |
| A | ASP123 |
| A | ILE124 |
| A | THR125 |
| A | GLU183 |
| A | ASN184 |
| B | PG4301 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| A | ARG129 |
| A | VAL130 |
| A | ASP189 |
| A | HOH433 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details |
| Chain | Residue |
| A | ARG129 |
| A | HOH483 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details |
| Chain | Residue |
| A | ARG93 |
| A | ARG101 |
| A | GLN149 |
| A | TYR168 |
| A | HOH404 |
| A | HOH463 |
| A | HOH480 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details |
| Chain | Residue |
| A | LYS140 |
| A | GLN200 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details |
| Chain | Residue |
| A | LYS121 |
| A | GLU183 |
| A | PEG307 |
| B | ARG129 |
| B | ASP177 |
| B | HOH404 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| A | LYS113 |
| B | SER103 |
| B | GLU174 |
| B | LYS178 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details |
| Chain | Residue |
| B | ILE12 |
| B | ASP13 |
| B | GLY14 |
| B | SER15 |
| B | GLY16 |
| B | LYS17 |
| B | SER18 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| A | SER117 |
| B | ASP108 |
| B | TRP111 |
| B | 1PE311 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details |
| Chain | Residue |
| A | SER131 |
| A | GLY170 |
| A | THR173 |
| A | GLU174 |
| B | LYS53 |
| B | ASP56 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| B | PRO132 |
| B | GLY170 |
| B | THR173 |
| B | HOH402 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details |
| Chain | Residue |
| B | LEU58 |
| B | PHE63 |
| B | ASP154 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details |
| Chain | Residue |
| B | SER117 |
| B | PHE118 |
| site_id | CC2 |
| Number of Residues | 1 |
| Details |
| Chain | Residue |
| B | HOH450 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| B | PHE71 |
| B | TYR94 |
| B | ARG101 |
| B | TYR116 |
| site_id | CC4 |
| Number of Residues | 7 |
| Details |
| Chain | Residue |
| A | LYS114 |
| A | SER117 |
| B | ASP110 |
| B | TRP111 |
| B | GLU174 |
| B | PEG304 |
| B | HOH431 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | GLY11 | |
| B | GLY11 |
