4NY9

Crystal Structure Of the Human PXR-LBD In Complex With N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-3-hydroxy-3-methylbutanamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 2Q4 A 501

Chain	Residue
A	VAL211
A	MET243
A	ALA244
A	GLN285
A	PHE288
A	TRP299
A	TYR306
A	HIS407
A	HOH605

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 502

Chain	Residue
A	THR161
A	PHE162
A	ASP163
A	TYR249
A	MET250
A	GLY253
A	ARG287

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:12578355, ECO:0007744|PDB:1M13

Chain	Residue	Details
A	SER247
A	GLN285
A	HIS407

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