4NWL
Crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0019087 | biological_process | transformation of host cell by virus |
| B | 0006508 | biological_process | proteolysis |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0019087 | biological_process | transformation of host cell by virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 2R9 A 301 |
| Chain | Residue |
| A | PHE43 |
| A | ARG155 |
| A | ALA156 |
| A | ALA157 |
| A | VAL158 |
| A | CYS159 |
| A | ASP168 |
| A | HOH410 |
| A | HOH436 |
| A | HOH446 |
| B | TYR6 |
| A | HIS57 |
| B | ALA7 |
| B | GLN8 |
| A | VAL78 |
| A | ASP81 |
| A | LEU135 |
| A | LYS136 |
| A | GLY137 |
| A | SER139 |
| A | PHE154 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | CYS97 |
| A | CYS99 |
| A | CYS145 |
| A | HIS149 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 2R9 B 301 |
| Chain | Residue |
| A | ARG-3 |
| A | TYR6 |
| A | ALA7 |
| A | GLN8 |
| B | PHE43 |
| B | TYR56 |
| B | HIS57 |
| B | GLY58 |
| B | VAL78 |
| B | ASP79 |
| B | ASP81 |
| B | LEU135 |
| B | LYS136 |
| B | GLY137 |
| B | SER139 |
| B | PHE154 |
| B | ARG155 |
| B | ALA156 |
| B | ALA157 |
| B | CYS159 |
| B | ASP168 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | CYS97 |
| B | CYS99 |
| B | CYS145 |
| B | HIS149 |
