4NU6
Crystal Structure of PTDH R301K
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0008465 | molecular_function | hydroxypyruvate reductase (NADH) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| A | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| A | 0050609 | molecular_function | phosphonate dehydrogenase activity |
| A | 0051287 | molecular_function | NAD binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008465 | molecular_function | hydroxypyruvate reductase (NADH) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| B | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| B | 0050609 | molecular_function | phosphonate dehydrogenase activity |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NAD A 500 |
| Chain | Residue |
| A | LYS76 |
| A | ALA207 |
| A | LEU208 |
| A | PRO209 |
| A | PRO235 |
| A | CYS236 |
| A | ARG237 |
| A | ASP261 |
| A | HIS292 |
| A | SO4501 |
| A | HOH602 |
| A | GLY77 |
| A | HOH607 |
| A | THR104 |
| A | MET153 |
| A | GLY154 |
| A | ALA155 |
| A | ILE156 |
| A | GLU175 |
| A | ALA176 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | LEU75 |
| A | LYS76 |
| A | GLY77 |
| A | LEU100 |
| A | ARG237 |
| A | NAD500 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAD B 500 |
| Chain | Residue |
| B | LYS76 |
| B | GLY77 |
| B | THR104 |
| B | GLY152 |
| B | MET153 |
| B | GLY154 |
| B | ALA155 |
| B | ILE156 |
| B | GLU175 |
| B | ALA176 |
| B | ALA207 |
| B | LEU208 |
| B | PRO209 |
| B | THR214 |
| B | PRO235 |
| B | CYS236 |
| B | ARG237 |
| B | ASP261 |
| B | HIS292 |
| B | GLY294 |
| B | SO4501 |
| B | HOH602 |
| B | HOH613 |
| B | HOH620 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 501 |
| Chain | Residue |
| B | LEU75 |
| B | LYS76 |
| B | GLY77 |
| B | LEU100 |
| B | ARG237 |
| B | NAD500 |
Functional Information from PROSITE/UniProt
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. VRpGaLLVNpCRGsVVD |
| Chain | Residue | Details |
| A | VAL226-ASP242 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
