4NTY
Cesium sites in the crystal structure of acid-sensing ion channel in complex with snake toxin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0015280 | molecular_function | ligand-gated sodium channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0090729 | molecular_function | toxin activity |
| B | 0099106 | molecular_function | ion channel regulator activity |
| C | 0004623 | molecular_function | phospholipase A2 activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005543 | molecular_function | phospholipid binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006644 | biological_process | phospholipid metabolic process |
| C | 0016042 | biological_process | lipid catabolic process |
| C | 0035821 | biological_process | modulation of process of another organism |
| C | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| C | 0050482 | biological_process | arachidonate secretion |
| C | 0090729 | molecular_function | toxin activity |
| C | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CS A 501 |
| Chain | Residue |
| A | TYR68 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS A 503 |
| Chain | Residue |
| A | THR295 |
| A | GLU299 |
| A | TYR301 |
| A | ASP302 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS A 504 |
| Chain | Residue |
| A | ASP238 |
| A | THR240 |
| A | PE4513 |
| A | HOH657 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS A 505 |
| Chain | Residue |
| A | TYR110 |
| A | HIS111 |
| A | TYR123 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS A 506 |
| Chain | Residue |
| A | LEU375 |
| A | LEU375 |
| A | LEU375 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CS A 507 |
| Chain | Residue |
| A | LYS373 |
| A | LYS373 |
| A | LYS373 |
| A | HOH654 |
| A | HOH654 |
| A | HOH654 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS A 508 |
| Chain | Residue |
| A | VAL319 |
| A | GLU320 |
| A | ASN323 |
| C | ASN3 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CS A 510 |
| Chain | Residue |
| A | GLU183 |
| A | PHE185 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 512 |
| Chain | Residue |
| A | LYS212 |
| A | ARG310 |
| A | HOH604 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PE4 A 513 |
| Chain | Residue |
| A | LEU96 |
| A | GLU98 |
| A | ARG191 |
| A | ASP238 |
| A | ASP350 |
| A | GLU354 |
| A | CS504 |
| A | HOH667 |
| A | HOH668 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS B 101 |
| Chain | Residue |
| B | GLN45 |
| B | HIS47 |
| B | PHE48 |
| B | HOH203 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CS B 102 |
| Chain | Residue |
| C | ASP31 |
| C | SER32 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS C 201 |
| Chain | Residue |
| B | SER29 |
| C | PHE68 |
| C | HOH304 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CS C 202 |
| Chain | Residue |
| C | SER80 |
| C | ASN82 |
Functional Information from PROSITE/UniProt
| site_id | PS00092 |
| Number of Residues | 7 |
| Details | N6_MTASE N-6 Adenine-specific DNA methylases signature. CYEDPPF |
| Chain | Residue | Details |
| B | CYS7-PHE13 |
| site_id | PS00119 |
| Number of Residues | 11 |
| Details | PA2_ASP Phospholipase A2 aspartic acid active site. VCNCDRTAtLC |
| Chain | Residue | Details |
| C | VAL90-CYS100 |
| site_id | PS01206 |
| Number of Residues | 21 |
| Details | ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC |
| Chain | Residue | Details |
| A | TYR304-CYS324 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"24507937","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4NTW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Motif: {"description":"GAS motif; ion selectivity filter","evidences":[{"source":"PubMed","id":"22842900","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24507937","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Involved in channel desensitization; the process by which the channel becomes unresponsive to proton stimulation","evidences":[{"source":"PubMed","id":"22842900","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Involved in proton-dependent gating","evidences":[{"source":"UniProtKB","id":"P78348","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17882215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22760635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22842900","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QTS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
