4NTO
Crystal structure of D60A mutant of Arabidopsis ACD11 (accelerated-cell-death 11) complexed with C2 ceramide-1-phosphate (d18:1/2:0) at 2.15 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006869 | biological_process | lipid transport |
| A | 0008219 | biological_process | cell death |
| A | 0008289 | molecular_function | lipid binding |
| A | 0009751 | biological_process | response to salicylic acid |
| A | 0015914 | biological_process | phospholipid transport |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0120009 | biological_process | intermembrane lipid transfer |
| A | 0120013 | molecular_function | lipid transfer activity |
| A | 0140338 | molecular_function | sphingomyelin transfer activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006869 | biological_process | lipid transport |
| B | 0008219 | biological_process | cell death |
| B | 0008289 | molecular_function | lipid binding |
| B | 0009751 | biological_process | response to salicylic acid |
| B | 0015914 | biological_process | phospholipid transport |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0120009 | biological_process | intermembrane lipid transfer |
| B | 0120013 | molecular_function | lipid transfer activity |
| B | 0140338 | molecular_function | sphingomyelin transfer activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006869 | biological_process | lipid transport |
| C | 0008219 | biological_process | cell death |
| C | 0008289 | molecular_function | lipid binding |
| C | 0009751 | biological_process | response to salicylic acid |
| C | 0015914 | biological_process | phospholipid transport |
| C | 0042742 | biological_process | defense response to bacterium |
| C | 0120009 | biological_process | intermembrane lipid transfer |
| C | 0120013 | molecular_function | lipid transfer activity |
| C | 0140338 | molecular_function | sphingomyelin transfer activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1PW A 301 |
| Chain | Residue |
| A | MET59 |
| C | LEU153 |
| C | TYR156 |
| A | LYS64 |
| A | ARG99 |
| A | ARG103 |
| A | HIS143 |
| A | ILE147 |
| A | 1PW302 |
| A | HOH421 |
| A | HOH502 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 1PW A 302 |
| Chain | Residue |
| A | ILE147 |
| A | 1PW301 |
| C | TRP145 |
| C | ARG148 |
| C | TYR156 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG A 303 |
| Chain | Residue |
| A | PRO141 |
| C | 1PW301 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1PW B 301 |
| Chain | Residue |
| A | LEU153 |
| A | TYR156 |
| B | GLY144 |
| B | TRP145 |
| B | TRP145 |
| B | ALA146 |
| B | ILE147 |
| B | ARG148 |
| B | 1PW302 |
| B | HOH490 |
| C | 1PW302 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1PW B 302 |
| Chain | Residue |
| A | TYR156 |
| B | MET59 |
| B | ALA60 |
| B | LYS64 |
| B | ARG99 |
| B | ARG103 |
| B | ILE147 |
| B | 1PW301 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG B 303 |
| Chain | Residue |
| B | SER152 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 1PW C 301 |
| Chain | Residue |
| A | TRP145 |
| A | ARG148 |
| A | PEG303 |
| A | HOH473 |
| B | TYR156 |
| C | HIS142 |
| C | HIS143 |
| C | GLY144 |
| C | ILE147 |
| C | ALA150 |
| C | HOH437 |
| C | HOH458 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1PW C 302 |
| Chain | Residue |
| B | TYR156 |
| B | 1PW301 |
| C | PHE56 |
| C | MET59 |
| C | ALA60 |
| C | LYS64 |
| C | ARG99 |
| C | ARG103 |
| C | ILE147 |
| C | HOH437 |
| C | HOH439 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 15 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24412362 |
| Chain | Residue | Details |
| A | ALA60 | |
| B | HIS143 | |
| C | ALA60 | |
| C | LYS64 | |
| C | ARG99 | |
| C | ARG103 | |
| C | HIS143 | |
| A | LYS64 | |
| A | ARG99 | |
| A | ARG103 | |
| A | HIS143 | |
| B | ALA60 | |
| B | LYS64 | |
| B | ARG99 | |
| B | ARG103 |
