4NTO

Crystal structure of D60A mutant of Arabidopsis ACD11 (accelerated-cell-death 11) complexed with C2 ceramide-1-phosphate (d18:1/2:0) at 2.15 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006869	biological_process	lipid transport
A	0008289	molecular_function	lipid binding
A	0009751	biological_process	response to salicylic acid
A	0015914	biological_process	phospholipid transport
A	0035627	biological_process	ceramide transport
A	0042742	biological_process	defense response to bacterium
A	0120009	biological_process	intermembrane lipid transfer
A	0120013	molecular_function	lipid transfer activity
A	0120014	molecular_function	phospholipid transfer activity
A	0120016	molecular_function	sphingolipid transfer activity
A	0140338	molecular_function	sphingomyelin transfer activity
A	1902387	molecular_function	ceramide 1-phosphate binding
A	1902388	molecular_function	ceramide 1-phosphate transfer activity
A	1902389	biological_process	ceramide 1-phosphate transport
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006869	biological_process	lipid transport
B	0008289	molecular_function	lipid binding
B	0009751	biological_process	response to salicylic acid
B	0015914	biological_process	phospholipid transport
B	0035627	biological_process	ceramide transport
B	0042742	biological_process	defense response to bacterium
B	0120009	biological_process	intermembrane lipid transfer
B	0120013	molecular_function	lipid transfer activity
B	0120014	molecular_function	phospholipid transfer activity
B	0120016	molecular_function	sphingolipid transfer activity
B	0140338	molecular_function	sphingomyelin transfer activity
B	1902387	molecular_function	ceramide 1-phosphate binding
B	1902388	molecular_function	ceramide 1-phosphate transfer activity
B	1902389	biological_process	ceramide 1-phosphate transport
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006869	biological_process	lipid transport
C	0008289	molecular_function	lipid binding
C	0009751	biological_process	response to salicylic acid
C	0015914	biological_process	phospholipid transport
C	0035627	biological_process	ceramide transport
C	0042742	biological_process	defense response to bacterium
C	0120009	biological_process	intermembrane lipid transfer
C	0120013	molecular_function	lipid transfer activity
C	0120014	molecular_function	phospholipid transfer activity
C	0120016	molecular_function	sphingolipid transfer activity
C	0140338	molecular_function	sphingomyelin transfer activity
C	1902387	molecular_function	ceramide 1-phosphate binding
C	1902388	molecular_function	ceramide 1-phosphate transfer activity
C	1902389	biological_process	ceramide 1-phosphate transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1PW A 301

Chain	Residue
A	MET59
C	LEU153
C	TYR156
A	LYS64
A	ARG99
A	ARG103
A	HIS143
A	ILE147
A	1PW302
A	HOH421
A	HOH502

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PW A 302

Chain	Residue
A	ILE147
A	1PW301
C	TRP145
C	ARG148
C	TYR156

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG A 303

Chain	Residue
A	PRO141
C	1PW301

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1PW B 301

Chain	Residue
A	LEU153
A	TYR156
B	GLY144
B	TRP145
B	TRP145
B	ALA146
B	ILE147
B	ARG148
B	1PW302
B	HOH490
C	1PW302

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 1PW B 302

Chain	Residue
A	TYR156
B	MET59
B	ALA60
B	LYS64
B	ARG99
B	ARG103
B	ILE147
B	1PW301

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG B 303

Chain	Residue
B	SER152

---

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 1PW C 301

Chain	Residue
A	TRP145
A	ARG148
A	PEG303
A	HOH473
B	TYR156
C	HIS142
C	HIS143
C	GLY144
C	ILE147
C	ALA150
C	HOH437
C	HOH458

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1PW C 302

Chain	Residue
B	TYR156
B	1PW301
C	PHE56
C	MET59
C	ALA60
C	LYS64
C	ARG99
C	ARG103
C	ILE147
C	HOH437
C	HOH439

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24412362","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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