4NTB

Mus Musculus LTC4 synthase in GSH complex form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004464	molecular_function	leukotriene-C4 synthase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005640	cellular_component	nuclear outer membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006691	biological_process	leukotriene metabolic process
A	0008047	molecular_function	enzyme activator activity
A	0008289	molecular_function	lipid binding
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0019370	biological_process	leukotriene biosynthetic process
A	0031965	cellular_component	nuclear membrane
A	0043295	molecular_function	glutathione binding
A	0044877	molecular_function	protein-containing complex binding
A	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NI A 201

Chain	Residue
A	HIS1
A	HIS1

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 202

Chain	Residue
A	ARG48
A	SER100
A	SER100
A	ALA101
A	ALA101
A	GLN102

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GSH A 203

Chain	Residue
A	ILE27
A	ARG30
A	PHE50
A	ARG51
A	GLN53
A	ASN55
A	GLU58
A	TYR59
A	TYR93
A	TYR97
A	ARG104
A	LEU108
A	SER23

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLM A 204

Chain	Residue
A	LYS2
A	VAL128
A	PRO132
A	LEU135
A	ARG136

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PLM A 205

Chain	Residue
A	LEU7
A	THR10
A	LEU127
A	PHE130

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PLM A 206

Chain	Residue
A	LEU18
A	GLN95

---

Functional Information from PROSITE/UniProt

site_id	PS01297
Number of Residues	15
Details	FLAP_GST2_LTC4S FLAP/GST2/LTC4S family signature. GppeFERVFrAQvNC

Chain	Residue	Details
A	GLY42-CYS56

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	79
Details	TRANSMEM: Helical => ECO:0000250|UniProtKB:Q16873

Chain	Residue	Details
A	LEU7-ILE27
A	VAL49-VAL69
A	PHE74-PHE94
A	LEU105-LEU124

---

site_id	SWS_FT_FI2
Number of Residues	29
Details	TOPO_DOM: Lumenal => ECO:0000250|UniProtKB:Q16873

Chain	Residue	Details
A	SER28-ARG48
A	GLN95-ARG104

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q16873

Chain	Residue	Details
A	ALA70-PHE73
A	GLY125-ALA150

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q16873

Chain	Residue	Details
A	ARG31

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q16873

Chain	Residue	Details
A	ARG104

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q16873

Chain	Residue	Details
A	GLN53
A	GLU58
A	TYR93
A	ARG30
A	ARG51

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q16873

Chain	Residue	Details
A	SER36

---