4NS3
Crystal structure of the Delta-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis bound with NAD and cobalamin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003842 | molecular_function | L-glutamate gamma-semialdehyde dehydrogenase activity |
| A | 0004657 | molecular_function | proline dehydrogenase activity |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0010133 | biological_process | obsolete L-proline catabolic process to L-glutamate |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0003842 | molecular_function | L-glutamate gamma-semialdehyde dehydrogenase activity |
| B | 0004657 | molecular_function | proline dehydrogenase activity |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0010133 | biological_process | obsolete L-proline catabolic process to L-glutamate |
| B | 0016491 | molecular_function | oxidoreductase activity |
| C | 0003842 | molecular_function | L-glutamate gamma-semialdehyde dehydrogenase activity |
| C | 0004657 | molecular_function | proline dehydrogenase activity |
| C | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| C | 0010133 | biological_process | obsolete L-proline catabolic process to L-glutamate |
| C | 0016491 | molecular_function | oxidoreductase activity |
| D | 0003842 | molecular_function | L-glutamate gamma-semialdehyde dehydrogenase activity |
| D | 0004657 | molecular_function | proline dehydrogenase activity |
| D | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| D | 0010133 | biological_process | obsolete L-proline catabolic process to L-glutamate |
| D | 0016491 | molecular_function | oxidoreductase activity |
| E | 0003842 | molecular_function | L-glutamate gamma-semialdehyde dehydrogenase activity |
| E | 0004657 | molecular_function | proline dehydrogenase activity |
| E | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| E | 0010133 | biological_process | obsolete L-proline catabolic process to L-glutamate |
| E | 0016491 | molecular_function | oxidoreductase activity |
| F | 0003842 | molecular_function | L-glutamate gamma-semialdehyde dehydrogenase activity |
| F | 0004657 | molecular_function | proline dehydrogenase activity |
| F | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| F | 0010133 | biological_process | obsolete L-proline catabolic process to L-glutamate |
| F | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE B12 A 601 |
| Chain | Residue |
| A | ILE186 |
| A | HOH750 |
| A | HOH770 |
| A | HOH771 |
| A | HOH798 |
| A | HOH864 |
| A | HOH876 |
| A | HOH935 |
| A | HOH970 |
| A | HOH1007 |
| A | HOH1015 |
| A | PHE246 |
| A | HOH1022 |
| A | HOH1080 |
| A | HOH1174 |
| C | LYS386 |
| C | GLU398 |
| C | TYR399 |
| C | HOH1063 |
| A | ASP250 |
| A | ALA268 |
| A | THR269 |
| A | HIS272 |
| A | HOH701 |
| A | HOH720 |
| A | HOH746 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE B12 B 601 |
| Chain | Residue |
| B | PHE246 |
| B | ASP250 |
| B | THR269 |
| B | HIS272 |
| B | ARG373 |
| B | HOH714 |
| B | HOH750 |
| B | HOH767 |
| B | HOH771 |
| B | HOH775 |
| B | HOH794 |
| B | HOH842 |
| B | HOH843 |
| B | HOH993 |
| B | HOH1049 |
| B | HOH1080 |
| B | HOH1117 |
| B | HOH1138 |
| C | ASP37 |
| C | PRO39 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE B12 C 601 |
| Chain | Residue |
| C | PHE246 |
| C | ASP250 |
| C | THR269 |
| C | HIS272 |
| C | ARG373 |
| C | HOH766 |
| C | HOH776 |
| C | HOH815 |
| C | HOH822 |
| C | HOH985 |
| C | HOH1000 |
| C | HOH1074 |
| C | HOH1162 |
| D | ASN280 |
| D | ARG283 |
| site_id | AC4 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE B12 D 601 |
| Chain | Residue |
| C | ALA79 |
| C | ASP250 |
| C | VAL251 |
| C | ALA254 |
| C | ASP255 |
| C | PRO256 |
| C | ARG283 |
| D | ILE186 |
| D | PHE246 |
| D | ASP250 |
| D | ALA268 |
| D | THR269 |
| D | HIS272 |
| D | ARG373 |
| D | HOH703 |
| D | HOH737 |
| D | HOH778 |
| D | HOH795 |
| D | HOH801 |
| D | HOH891 |
| D | HOH931 |
| D | HOH961 |
| D | HOH994 |
| D | HOH1054 |
| D | HOH1058 |
| D | HOH1061 |
| D | HOH1139 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NAD E 601 |
| Chain | Residue |
| E | SER266 |
| E | THR269 |
| E | HIS272 |
| E | HOH998 |
| E | HOH1016 |
| E | TYR184 |
| E | ILE186 |
| E | THR187 |
| E | PRO188 |
| E | PHE189 |
| E | ASN190 |
| E | LYS212 |
| E | SER214 |
| E | GLY245 |
| E | SER249 |
| E | PHE263 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE NAD F 601 |
| Chain | Residue |
| F | TYR184 |
| F | ILE186 |
| F | THR187 |
| F | PHE189 |
| F | ASN190 |
| F | LYS212 |
| F | SER214 |
| F | GLY245 |
| F | SER249 |
| F | PHE263 |
| F | GLY265 |
| F | SER266 |
| F | THR269 |
| F | HIS272 |
| F | CME327 |
| F | HOH891 |
| F | HOH1032 |
Functional Information from PROSITE/UniProt
| site_id | PS00070 |
| Number of Residues | 12 |
| Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FdYQGQKCSAVS |
| Chain | Residue | Details |
| A | PHE320-SER331 |
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GETGGKDF |
| Chain | Residue | Details |
| A | GLY292-PHE299 |
