4NS1
Crystal structure of purine nucleoside phosphorylase from Porphyromonas gingivalis ATCC 33277, NYSGRC Target 30972
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0016763 | molecular_function | pentosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE DA A 301 |
| Chain | Residue |
| A | ALA129 |
| A | ASN250 |
| A | HOH716 |
| A | ALA130 |
| A | GLY131 |
| A | GLU208 |
| A | TYR213 |
| A | ILE224 |
| A | GLY225 |
| A | MSE226 |
| A | THR249 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | GLY45 |
| A | SER46 |
| A | ARG97 |
| A | HIS99 |
| A | ASN128 |
| A | ALA129 |
| A | SER227 |
| A | HOH565 |
| A | HOH650 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 303 |
| Chain | Residue |
| A | ARG236 |
| A | HOH437 |
| A | HOH446 |
| A | HOH474 |
| A | HOH530 |
| A | HOH543 |
| A | HOH670 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 304 |
| Chain | Residue |
| A | HIS254 |
| A | PHE255 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 305 |
| Chain | Residue |
| A | ILE55 |
| A | GLU56 |
| A | ASN57 |
| A | LYS58 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 306 |
| Chain | Residue |
| A | GLN218 |
| B | GLN218 |
| C | GLN218 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE DA B 301 |
| Chain | Residue |
| B | ALA129 |
| B | ALA130 |
| B | GLY131 |
| B | GLU208 |
| B | TYR213 |
| B | ILE224 |
| B | GLY225 |
| B | MSE226 |
| B | THR249 |
| B | ASN250 |
| B | HOH639 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| B | GLY45 |
| B | SER46 |
| B | ARG97 |
| B | HIS99 |
| B | ASN128 |
| B | ALA129 |
| B | SER227 |
| B | HOH591 |
| B | HOH599 |
| B | HOH601 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 303 |
| Chain | Residue |
| B | HIS254 |
| B | PHE255 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 304 |
| Chain | Residue |
| B | ARG236 |
| B | GLY239 |
| B | HOH417 |
| B | HOH506 |
| B | HOH542 |
| B | HOH596 |
| B | HOH775 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 305 |
| Chain | Residue |
| A | ILE186 |
| A | GLU189 |
| A | ARG283 |
| A | ALA287 |
| B | ILE186 |
| B | GLU189 |
| B | ARG283 |
| site_id | BC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE DA C 301 |
| Chain | Residue |
| C | ALA129 |
| C | ALA130 |
| C | GLY131 |
| C | GLU208 |
| C | TYR213 |
| C | ILE224 |
| C | GLY225 |
| C | MSE226 |
| C | THR249 |
| C | ASN250 |
| C | HOH597 |
| site_id | BC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 C 302 |
| Chain | Residue |
| C | GLY45 |
| C | SER46 |
| C | ARG97 |
| C | HIS99 |
| C | ASN128 |
| C | ALA129 |
| C | SER227 |
| C | HOH516 |
| C | HOH553 |
| C | HOH566 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL C 303 |
| Chain | Residue |
| C | HIS254 |
| C | PHE255 |
| C | HOH403 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL C 304 |
| Chain | Residue |
| C | LYS58 |
| C | GLU56 |
| C | ASN57 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 305 |
| Chain | Residue |
| C | ARG236 |
| C | GLY239 |
| C | HOH463 |
| C | HOH526 |
| C | HOH586 |
| C | HOH665 |
| C | HOH683 |
| site_id | BC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE DA D 301 |
| Chain | Residue |
| D | ALA129 |
| D | ALA130 |
| D | GLY131 |
| D | GLU208 |
| D | TYR213 |
| D | ILE224 |
| D | GLY225 |
| D | MSE226 |
| D | THR249 |
| D | ASN250 |
| D | HOH733 |
| site_id | BC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 D 302 |
| Chain | Residue |
| D | GLY45 |
| D | SER46 |
| D | ARG97 |
| D | HIS99 |
| D | ASN128 |
| D | ALA129 |
| D | SER227 |
| D | HOH670 |
| D | HOH677 |
| D | HOH740 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 303 |
| Chain | Residue |
| D | GLN218 |
| D | GLN218 |
| D | GLN218 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 304 |
| Chain | Residue |
| D | ASN151 |
| D | ASN151 |
| D | ASN151 |
| D | TRP216 |
| D | TRP216 |
| D | TRP216 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL D 305 |
| Chain | Residue |
| D | HIS254 |
| D | PHE255 |
| D | HOH404 |
| site_id | CC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL D 306 |
| Chain | Residue |
| D | ARG236 |
| D | GLY239 |
| D | ARG241 |
| D | HOH410 |
| D | HOH498 |
| D | HOH547 |
| D | HOH678 |
| D | HOH720 |
| D | HOH741 |
Functional Information from PROSITE/UniProt
| site_id | PS01240 |
| Number of Residues | 42 |
| Details | PNP_MTAP_2 Purine and other phosphorylases family 2 signature. VamqGrfHyYegysMdqvTfpIrVmkllGien.LFvsNAaGGI |
| Chain | Residue | Details |
| A | VAL92-ILE133 |
