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4NR8

Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand

Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K A 201
ChainResidue
ALYS57
ALYS99
ALYS102

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 2LL A 202
ChainResidue
ALEU92
AASN140
AHOH321
AHOH393
AGLN59
AGLN64
AARG68
ATRP81
APRO82
ALYS91

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 203
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH358

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

224004

PDB entries from 2024-08-21

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