4NR7

Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1201

Chain	Residue
A	ARG1091
A	MET1095
A	PRO1096
A	ASP1124
A	HOH1316
A	HOH1348

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1202

Chain	Residue
A	LYS1141
A	GLN1146
A	HOH1318

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1203

Chain	Residue
A	GLU1107
A	ASN1162
A	TRP1165
A	LEU1166
A	HOH1371
A	HOH1401
A	HOH1469

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 2LO A 1204

Chain	Residue
A	LEU1109
A	PRO1110
A	VAL1115
A	LEU1120
A	ILE1122
A	TYR1125
A	ASN1168
A	ARG1173
A	VAL1174
A	PHE1177
A	HOH1306
A	HOH1498
A	HOH1501

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY

Chain	Residue	Details
A	SER1108-TYR1167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	107
Details	Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	46
Details	Region: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"24361270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Region: {"description":"Interaction with ASF1A","evidences":[{"source":"PubMed","id":"24616510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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