4NR2

Crystal structure of STK4 (MST1) SARAH domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0007165	biological_process	signal transduction
A	0051262	biological_process	protein tetramerization
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0007165	biological_process	signal transduction
B	0051262	biological_process	protein tetramerization
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0007165	biological_process	signal transduction
C	0051262	biological_process	protein tetramerization
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0007165	biological_process	signal transduction
D	0051262	biological_process	protein tetramerization
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0007165	biological_process	signal transduction
E	0051262	biological_process	protein tetramerization
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0007165	biological_process	signal transduction
F	0051262	biological_process	protein tetramerization
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0007165	biological_process	signal transduction
G	0051262	biological_process	protein tetramerization
H	0004674	molecular_function	protein serine/threonine kinase activity
H	0007165	biological_process	signal transduction
H	0051262	biological_process	protein tetramerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 501

Chain	Residue
A	LEU451
A	ASP452
A	MET455
A	HOH642
B	ARG470
B	EDO501

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 502

Chain	Residue
A	LYS465
B	GLU458
E	PHE435

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 503

Chain	Residue
A	ARG470
A	HOH603
A	HOH638
B	ASP452
B	MET455

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 504

Chain	Residue
A	LYS446
A	ARG447
A	ALA450
A	HOH602
E	PRO453
E	MET454
E	GLN457

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 501

Chain	Residue
A	ASP452
A	EDO501
A	HOH642
B	ARG470
D	LEU449
D	ASP452
D	PRO453

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 501

Chain	Residue
A	HOH635
C	ARG470
D	LEU451
D	ASP452
D	MET455
D	HOH507

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 501

Chain	Residue
A	MET454
E	MET0
E	ARG447
E	HOH620
F	LYS469

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO F 501

Chain	Residue
F	PHE435
F	ARG463
F	GLN464
F	GLN467

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO H 501

Chain	Residue
C	MET454
D	HOH513
G	LYS469
G	HOH517
H	MET0
H	ARG447

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO H 502

Chain	Residue
G	ARG470
H	LEU451
H	ASP452
H	MET455
H	HOH605

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	282
Details	Domain: {"description":"SARAH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00310","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9JI11","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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