Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4NQZ

Crystal Structure of the Pseudomonas aeruginosa Enoyl-Acyl Carrier Protein Reductase (FabI) in apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0030497	biological_process	fatty acid elongation
A	0042802	molecular_function	identical protein binding
B	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B	0006633	biological_process	fatty acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0030497	biological_process	fatty acid elongation
B	0042802	molecular_function	identical protein binding
C	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C	0006633	biological_process	fatty acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0030497	biological_process	fatty acid elongation
C	0042802	molecular_function	identical protein binding
D	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D	0006633	biological_process	fatty acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0030497	biological_process	fatty acid elongation
D	0042802	molecular_function	identical protein binding
E	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E	0006633	biological_process	fatty acid biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0030497	biological_process	fatty acid elongation
E	0042802	molecular_function	identical protein binding
F	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F	0006633	biological_process	fatty acid biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0030497	biological_process	fatty acid elongation
F	0042802	molecular_function	identical protein binding
G	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G	0006633	biological_process	fatty acid biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0030497	biological_process	fatty acid elongation
G	0042802	molecular_function	identical protein binding
H	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H	0006633	biological_process	fatty acid biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0030497	biological_process	fatty acid elongation
H	0042802	molecular_function	identical protein binding
I	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I	0006633	biological_process	fatty acid biosynthetic process
I	0016491	molecular_function	oxidoreductase activity
I	0030497	biological_process	fatty acid elongation
I	0042802	molecular_function	identical protein binding
J	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J	0006633	biological_process	fatty acid biosynthetic process
J	0016491	molecular_function	oxidoreductase activity
J	0030497	biological_process	fatty acid elongation
J	0042802	molecular_function	identical protein binding
K	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K	0006633	biological_process	fatty acid biosynthetic process
K	0016491	molecular_function	oxidoreductase activity
K	0030497	biological_process	fatty acid elongation
K	0042802	molecular_function	identical protein binding
L	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L	0006633	biological_process	fatty acid biosynthetic process
L	0016491	molecular_function	oxidoreductase activity
L	0030497	biological_process	fatty acid elongation
L	0042802	molecular_function	identical protein binding
M	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M	0006633	biological_process	fatty acid biosynthetic process
M	0016491	molecular_function	oxidoreductase activity
M	0030497	biological_process	fatty acid elongation
M	0042802	molecular_function	identical protein binding
N	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N	0006633	biological_process	fatty acid biosynthetic process
N	0016491	molecular_function	oxidoreductase activity
N	0030497	biological_process	fatty acid elongation
N	0042802	molecular_function	identical protein binding
O	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O	0006633	biological_process	fatty acid biosynthetic process
O	0016491	molecular_function	oxidoreductase activity
O	0030497	biological_process	fatty acid elongation
O	0042802	molecular_function	identical protein binding
P	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
P	0006633	biological_process	fatty acid biosynthetic process
P	0016491	molecular_function	oxidoreductase activity
P	0030497	biological_process	fatty acid elongation
P	0042802	molecular_function	identical protein binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	TYR149
E	TYR159
F	TYR149
F	TYR159
G	TYR149
G	TYR159
H	TYR149
H	TYR159
I	TYR149
I	TYR159
J	TYR149
A	TYR159
J	TYR159
K	TYR149
K	TYR159
L	TYR149
L	TYR159
M	TYR149
M	TYR159
N	TYR149
N	TYR159
O	TYR149
B	TYR149
O	TYR159
P	TYR149
P	TYR159
B	TYR159
C	TYR149
C	TYR159
D	TYR149
D	TYR159
E	TYR149

site_id	SWS_FT_FI2
Number of Residues	128
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLY13
B	SER19
M	ASP66
M	VAL94
M	ALA97
M	LYS166
M	ILE195
N	GLY13
N	SER19
N	GLN40
N	ASP66
N	VAL94
B	GLN40
N	ALA97
N	LYS166
N	ILE195
O	GLY13
O	SER19
O	GLN40
O	ASP66
O	VAL94
O	ALA97
O	LYS166
B	ASP66
O	ILE195
P	GLY13
P	SER19
P	GLN40
P	ASP66
P	VAL94
P	ALA97
P	LYS166
P	ILE195
B	VAL94
B	ALA97
B	LYS166
B	ILE195
C	GLY13
C	SER19
C	GLN40
A	SER19
C	ASP66
C	VAL94
C	ALA97
C	LYS166
C	ILE195
D	GLY13
D	SER19
D	GLN40
D	ASP66
D	VAL94
A	GLN40
D	ALA97
D	LYS166
D	ILE195
E	GLY13
E	SER19
E	GLN40
E	ASP66
E	VAL94
E	ALA97
E	LYS166
A	ASP66
E	ILE195
F	GLY13
F	SER19
F	GLN40
F	ASP66
F	VAL94
F	ALA97
F	LYS166
F	ILE195
G	GLY13
A	VAL94
G	SER19
G	GLN40
G	ASP66
G	VAL94
G	ALA97
G	LYS166
G	ILE195
H	GLY13
H	SER19
H	GLN40
A	ALA97
H	ASP66
H	VAL94
H	ALA97
H	LYS166
H	ILE195
I	GLY13
I	SER19
I	GLN40
I	ASP66
I	VAL94
A	LYS166
I	ALA97
I	LYS166
I	ILE195
J	GLY13
J	SER19
J	GLN40
J	ASP66
J	VAL94
J	ALA97
J	LYS166
A	ILE195
J	ILE195
K	GLY13
K	SER19
K	GLN40
K	ASP66
K	VAL94
K	ALA97
K	LYS166
K	ILE195
L	GLY13
B	GLY13
L	SER19
L	GLN40
L	ASP66
L	VAL94
L	ALA97
L	LYS166
L	ILE195
M	GLY13
M	SER19
M	GLN40

site_id	SWS_FT_FI3
Number of Residues	48
Details	SITE: Involved in acyl-ACP binding => ECO:0000250

Chain	Residue	Details
A	LYS204
D	LYS204
D	ARG207
D	LYS208
E	LYS204
E	ARG207
E	LYS208
F	LYS204
F	ARG207
F	LYS208
G	LYS204
A	ARG207
G	ARG207
G	LYS208
H	LYS204
H	ARG207
H	LYS208
I	LYS204
I	ARG207
I	LYS208
J	LYS204
J	ARG207
A	LYS208
J	LYS208
K	LYS204
K	ARG207
K	LYS208
L	LYS204
L	ARG207
L	LYS208
M	LYS204
M	ARG207
M	LYS208
B	LYS204
N	LYS204
N	ARG207
N	LYS208
O	LYS204
O	ARG207
O	LYS208
P	LYS204
P	ARG207
P	LYS208
B	ARG207
B	LYS208
C	LYS204
C	ARG207
C	LYS208

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)