4NPV

Crystal structure of human PDE1B bound to inhibitor 7A (6,7,8-trimethoxy-N-(pentan-3-yl)quinazolin-4-amine)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 0NK A 601

Chain	Residue
A	TYR222
A	HOH713
A	HOH799
A	HIS223
A	ASP370
A	ILE371
A	HIS373
A	LEU388
A	MET389
A	GLN421
A	PHE424

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 602

Chain	Residue
A	ASP264
A	HOH707
A	HOH708
A	HOH709
A	HOH710
A	HOH711

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 603

Chain	Residue
A	HIS227
A	HIS263
A	ASP264
A	ASP370
A	HOH708
A	HOH712

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Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDYeHtGttNsF

Chain	Residue	Details
A	HIS263-PHE274

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083

Chain	Residue	Details
A	HIS223

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW

Chain	Residue	Details
A	ASP264
A	ASP370
A	HIS227
A	HIS263

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q01065

Chain	Residue	Details
A	SER466

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