4NO4

Crystal Structure of Galectin-1 L11A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002317	biological_process	plasma cell differentiation
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0006915	biological_process	apoptotic process
A	0009410	biological_process	response to xenobiotic stimulus
A	0009986	cellular_component	cell surface
A	0010812	biological_process	negative regulation of cell-substrate adhesion
A	0010977	biological_process	negative regulation of neuron projection development
A	0030246	molecular_function	carbohydrate binding
A	0030395	molecular_function	lactose binding
A	0031295	biological_process	T cell costimulation
A	0034120	biological_process	positive regulation of erythrocyte aggregation
A	0035900	biological_process	response to isolation stress
A	0042802	molecular_function	identical protein binding
A	0043065	biological_process	positive regulation of apoptotic process
A	0043236	molecular_function	laminin binding
A	0045185	biological_process	maintenance of protein location
A	0045445	biological_process	myoblast differentiation
A	0046598	biological_process	positive regulation of viral entry into host cell
A	0048678	biological_process	response to axon injury
A	0050729	biological_process	positive regulation of inflammatory response
A	0071333	biological_process	cellular response to glucose stimulus
A	0071407	biological_process	cellular response to organic cyclic compound
A	0098609	biological_process	cell-cell adhesion
A	1990724	cellular_component	galectin complex
A	2001200	biological_process	positive regulation of dendritic cell differentiation
B	0002317	biological_process	plasma cell differentiation
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0006915	biological_process	apoptotic process
B	0009410	biological_process	response to xenobiotic stimulus
B	0009986	cellular_component	cell surface
B	0010812	biological_process	negative regulation of cell-substrate adhesion
B	0010977	biological_process	negative regulation of neuron projection development
B	0030246	molecular_function	carbohydrate binding
B	0030395	molecular_function	lactose binding
B	0031295	biological_process	T cell costimulation
B	0034120	biological_process	positive regulation of erythrocyte aggregation
B	0035900	biological_process	response to isolation stress
B	0042802	molecular_function	identical protein binding
B	0043065	biological_process	positive regulation of apoptotic process
B	0043236	molecular_function	laminin binding
B	0045185	biological_process	maintenance of protein location
B	0045445	biological_process	myoblast differentiation
B	0046598	biological_process	positive regulation of viral entry into host cell
B	0048678	biological_process	response to axon injury
B	0050729	biological_process	positive regulation of inflammatory response
B	0071333	biological_process	cellular response to glucose stimulus
B	0071407	biological_process	cellular response to organic cyclic compound
B	0098609	biological_process	cell-cell adhesion
B	1990724	cellular_component	galectin complex
B	2001200	biological_process	positive regulation of dendritic cell differentiation
C	0002317	biological_process	plasma cell differentiation
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0006915	biological_process	apoptotic process
C	0009410	biological_process	response to xenobiotic stimulus
C	0009986	cellular_component	cell surface
C	0010812	biological_process	negative regulation of cell-substrate adhesion
C	0010977	biological_process	negative regulation of neuron projection development
C	0030246	molecular_function	carbohydrate binding
C	0030395	molecular_function	lactose binding
C	0031295	biological_process	T cell costimulation
C	0034120	biological_process	positive regulation of erythrocyte aggregation
C	0035900	biological_process	response to isolation stress
C	0042802	molecular_function	identical protein binding
C	0043065	biological_process	positive regulation of apoptotic process
C	0043236	molecular_function	laminin binding
C	0045185	biological_process	maintenance of protein location
C	0045445	biological_process	myoblast differentiation
C	0046598	biological_process	positive regulation of viral entry into host cell
C	0048678	biological_process	response to axon injury
C	0050729	biological_process	positive regulation of inflammatory response
C	0071333	biological_process	cellular response to glucose stimulus
C	0071407	biological_process	cellular response to organic cyclic compound
C	0098609	biological_process	cell-cell adhesion
C	1990724	cellular_component	galectin complex
C	2001200	biological_process	positive regulation of dendritic cell differentiation
D	0002317	biological_process	plasma cell differentiation
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0006915	biological_process	apoptotic process
D	0009410	biological_process	response to xenobiotic stimulus
D	0009986	cellular_component	cell surface
D	0010812	biological_process	negative regulation of cell-substrate adhesion
D	0010977	biological_process	negative regulation of neuron projection development
D	0030246	molecular_function	carbohydrate binding
D	0030395	molecular_function	lactose binding
D	0031295	biological_process	T cell costimulation
D	0034120	biological_process	positive regulation of erythrocyte aggregation
D	0035900	biological_process	response to isolation stress
D	0042802	molecular_function	identical protein binding
D	0043065	biological_process	positive regulation of apoptotic process
D	0043236	molecular_function	laminin binding
D	0045185	biological_process	maintenance of protein location
D	0045445	biological_process	myoblast differentiation
D	0046598	biological_process	positive regulation of viral entry into host cell
D	0048678	biological_process	response to axon injury
D	0050729	biological_process	positive regulation of inflammatory response
D	0071333	biological_process	cellular response to glucose stimulus
D	0071407	biological_process	cellular response to organic cyclic compound
D	0098609	biological_process	cell-cell adhesion
D	1990724	cellular_component	galectin complex
D	2001200	biological_process	positive regulation of dendritic cell differentiation
E	0002317	biological_process	plasma cell differentiation
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0006915	biological_process	apoptotic process
E	0009410	biological_process	response to xenobiotic stimulus
E	0009986	cellular_component	cell surface
E	0010812	biological_process	negative regulation of cell-substrate adhesion
E	0010977	biological_process	negative regulation of neuron projection development
E	0030246	molecular_function	carbohydrate binding
E	0030395	molecular_function	lactose binding
E	0031295	biological_process	T cell costimulation
E	0034120	biological_process	positive regulation of erythrocyte aggregation
E	0035900	biological_process	response to isolation stress
E	0042802	molecular_function	identical protein binding
E	0043065	biological_process	positive regulation of apoptotic process
E	0043236	molecular_function	laminin binding
E	0045185	biological_process	maintenance of protein location
E	0045445	biological_process	myoblast differentiation
E	0046598	biological_process	positive regulation of viral entry into host cell
E	0048678	biological_process	response to axon injury
E	0050729	biological_process	positive regulation of inflammatory response
E	0071333	biological_process	cellular response to glucose stimulus
E	0071407	biological_process	cellular response to organic cyclic compound
E	0098609	biological_process	cell-cell adhesion
E	1990724	cellular_component	galectin complex
E	2001200	biological_process	positive regulation of dendritic cell differentiation
F	0002317	biological_process	plasma cell differentiation
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0006915	biological_process	apoptotic process
F	0009410	biological_process	response to xenobiotic stimulus
F	0009986	cellular_component	cell surface
F	0010812	biological_process	negative regulation of cell-substrate adhesion
F	0010977	biological_process	negative regulation of neuron projection development
F	0030246	molecular_function	carbohydrate binding
F	0030395	molecular_function	lactose binding
F	0031295	biological_process	T cell costimulation
F	0034120	biological_process	positive regulation of erythrocyte aggregation
F	0035900	biological_process	response to isolation stress
F	0042802	molecular_function	identical protein binding
F	0043065	biological_process	positive regulation of apoptotic process
F	0043236	molecular_function	laminin binding
F	0045185	biological_process	maintenance of protein location
F	0045445	biological_process	myoblast differentiation
F	0046598	biological_process	positive regulation of viral entry into host cell
F	0048678	biological_process	response to axon injury
F	0050729	biological_process	positive regulation of inflammatory response
F	0071333	biological_process	cellular response to glucose stimulus
F	0071407	biological_process	cellular response to organic cyclic compound
F	0098609	biological_process	cell-cell adhesion
F	1990724	cellular_component	galectin complex
F	2001200	biological_process	positive regulation of dendritic cell differentiation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
D	HIS45
D	HIS53
D	ASN62
D	TRP69
E	HIS45
E	HIS53
E	ASN62
E	TRP69
F	HIS45
F	HIS53
F	ASN62
F	TRP69
A	HIS45
A	HIS53
A	ASN62
A	TRP69
B	HIS45
B	HIS53
B	ASN62
B	TRP69
C	HIS45
C	HIS53
C	ASN62
C	TRP69

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P09382

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
F	ALA2

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site_id	SWS_FT_FI3
Number of Residues	18
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P16045

Chain	Residue	Details
A	LYS128
B	LYS13
B	LYS19
B	LYS128
C	LYS13
C	LYS19
C	LYS128
D	LYS13
D	LYS19
D	LYS128
E	LYS13
E	LYS19
E	LYS128
F	LYS128
A	LYS13
A	LYS19
F	LYS13
F	LYS19

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site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P09382

Chain	Residue	Details
A	LYS29
B	LYS29
C	LYS29
D	LYS29
E	LYS29
F	LYS29

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site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P09382

Chain	Residue	Details
A	SER30
B	SER30
C	SER30
F	SER30
D	SER30
E	SER30

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site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P16045

Chain	Residue	Details
A	LYS108
B	LYS108
C	LYS108
D	LYS108
E	LYS108
F	LYS108

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