4NNM
Tax-Interacting Protein-1 (TIP-1) PDZ domain bound to Y-iCAL36 (YPTSII) peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001650 | cellular_component | fibrillar center |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007266 | biological_process | Rho protein signal transduction |
| A | 0008013 | molecular_function | beta-catenin binding |
| A | 0009966 | biological_process | regulation of signal transduction |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0030178 | biological_process | negative regulation of Wnt signaling pathway |
| A | 0032489 | biological_process | regulation of Cdc42 protein signal transduction |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 2000009 | biological_process | negative regulation of protein localization to cell surface |
| B | 0001650 | cellular_component | fibrillar center |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007266 | biological_process | Rho protein signal transduction |
| B | 0008013 | molecular_function | beta-catenin binding |
| B | 0009966 | biological_process | regulation of signal transduction |
| B | 0016055 | biological_process | Wnt signaling pathway |
| B | 0030178 | biological_process | negative regulation of Wnt signaling pathway |
| B | 0032489 | biological_process | regulation of Cdc42 protein signal transduction |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 2000009 | biological_process | negative regulation of protein localization to cell surface |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 201 |
| Chain | Residue |
| A | SER114 |
| A | LEU115 |
| A | LYS117 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 201 |
| Chain | Residue |
| B | HOH303 |
| B | ASN27 |
| B | LEU28 |
| B | THR99 |
| B | ARG101 |
| B | ALA118 |
| B | GLN121 |
| site_id | AC3 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR CHAIN C OF TIP-1 PDZ DOMAIN |
| Chain | Residue |
| A | VAL14 |
| A | ARG16 |
| A | ILE29 |
| A | LEU30 |
| A | GLY31 |
| A | PHE32 |
| A | SER33 |
| A | ILE34 |
| A | GLY35 |
| A | GLY36 |
| A | GLN40 |
| A | GLN44 |
| A | ASN45 |
| A | THR59 |
| A | ARG60 |
| A | HIS91 |
| A | ARG95 |
| A | LEU98 |
| A | THR99 |
| A | GLN120 |
| A | GLN121 |
| A | HOH319 |
| A | HOH356 |
| A | HOH385 |
| C | HOH101 |
| C | HOH102 |
| C | HOH104 |
| C | HOH105 |
| C | HOH106 |
| site_id | AC4 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR CHAIN D OF TIP-1 PDZ DOMAIN |
| Chain | Residue |
| B | VAL14 |
| B | ARG16 |
| B | ILE29 |
| B | LEU30 |
| B | GLY31 |
| B | PHE32 |
| B | SER33 |
| B | ILE34 |
| B | GLY35 |
| B | GLY36 |
| B | GLN40 |
| B | GLN44 |
| B | ASN45 |
| B | THR59 |
| B | ARG60 |
| B | HIS91 |
| B | ARG95 |
| B | LEU98 |
| B | THR99 |
| B | GLN120 |
| B | GLN121 |
| B | HOH369 |
| D | HOH101 |
| D | HOH102 |
| D | HOH103 |
| D | HOH104 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 194 |
| Details | Domain: {"description":"PDZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
