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4NNM

Tax-Interacting Protein-1 (TIP-1) PDZ domain bound to Y-iCAL36 (YPTSII) peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0001650cellular_componentfibrillar center
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0007266biological_processRho protein signal transduction
A0008013molecular_functionbeta-catenin binding
A0008285biological_processnegative regulation of cell population proliferation
A0015629cellular_componentactin cytoskeleton
A0016055biological_processWnt signaling pathway
A0030178biological_processnegative regulation of Wnt signaling pathway
A0043231cellular_componentintracellular membrane-bounded organelle
A0070062cellular_componentextracellular exosome
A0090630biological_processactivation of GTPase activity
A2000009biological_processnegative regulation of protein localization to cell surface
B0001650cellular_componentfibrillar center
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0007266biological_processRho protein signal transduction
B0008013molecular_functionbeta-catenin binding
B0008285biological_processnegative regulation of cell population proliferation
B0015629cellular_componentactin cytoskeleton
B0016055biological_processWnt signaling pathway
B0030178biological_processnegative regulation of Wnt signaling pathway
B0043231cellular_componentintracellular membrane-bounded organelle
B0070062cellular_componentextracellular exosome
B0090630biological_processactivation of GTPase activity
B2000009biological_processnegative regulation of protein localization to cell surface
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 201
ChainResidue
ASER114
ALEU115
ALYS117

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL B 201
ChainResidue
BHOH303
BASN27
BLEU28
BTHR99
BARG101
BALA118
BGLN121

site_idAC3
Number of Residues29
DetailsBINDING SITE FOR CHAIN C OF TIP-1 PDZ DOMAIN
ChainResidue
AVAL14
AARG16
AILE29
ALEU30
AGLY31
APHE32
ASER33
AILE34
AGLY35
AGLY36
AGLN40
AGLN44
AASN45
ATHR59
AARG60
AHIS91
AARG95
ALEU98
ATHR99
AGLN120
AGLN121
AHOH319
AHOH356
AHOH385
CHOH101
CHOH102
CHOH104
CHOH105
CHOH106

site_idAC4
Number of Residues26
DetailsBINDING SITE FOR CHAIN D OF TIP-1 PDZ DOMAIN
ChainResidue
BVAL14
BARG16
BILE29
BLEU30
BGLY31
BPHE32
BSER33
BILE34
BGLY35
BGLY36
BGLN40
BGLN44
BASN45
BTHR59
BARG60
BHIS91
BARG95
BLEU98
BTHR99
BGLN120
BGLN121
BHOH369
DHOH101
DHOH102
DHOH103
DHOH104

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER62
BSER62

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PDB entries from 2024-07-17

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