Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4NMH

11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005496	molecular_function	steroid binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006704	biological_process	glucocorticoid biosynthetic process
A	0006706	biological_process	steroid catabolic process
A	0006713	biological_process	glucocorticoid catabolic process
A	0008202	biological_process	steroid metabolic process
A	0008212	biological_process	mineralocorticoid metabolic process
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0030324	biological_process	lung development
A	0031965	cellular_component	nuclear membrane
A	0042803	molecular_function	protein homodimerization activity
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0043456	biological_process	regulation of pentose-phosphate shunt
A	0045177	cellular_component	apical part of cell
A	0047022	molecular_function	7-beta-hydroxysteroid dehydrogenase (NADP+) activity
A	0050661	molecular_function	NADP binding
A	0070524	molecular_function	11-beta-hydroxysteroid dehydrogenase (NADP+) activity
A	0102196	molecular_function	cortisol dehydrogenase activity
B	0005496	molecular_function	steroid binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006704	biological_process	glucocorticoid biosynthetic process
B	0006706	biological_process	steroid catabolic process
B	0006713	biological_process	glucocorticoid catabolic process
B	0008202	biological_process	steroid metabolic process
B	0008212	biological_process	mineralocorticoid metabolic process
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0030324	biological_process	lung development
B	0031965	cellular_component	nuclear membrane
B	0042803	molecular_function	protein homodimerization activity
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0043456	biological_process	regulation of pentose-phosphate shunt
B	0045177	cellular_component	apical part of cell
B	0047022	molecular_function	7-beta-hydroxysteroid dehydrogenase (NADP+) activity
B	0050661	molecular_function	NADP binding
B	0070524	molecular_function	11-beta-hydroxysteroid dehydrogenase (NADP+) activity
B	0102196	molecular_function	cortisol dehydrogenase activity
C	0005496	molecular_function	steroid binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006704	biological_process	glucocorticoid biosynthetic process
C	0006706	biological_process	steroid catabolic process
C	0006713	biological_process	glucocorticoid catabolic process
C	0008202	biological_process	steroid metabolic process
C	0008212	biological_process	mineralocorticoid metabolic process
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0030324	biological_process	lung development
C	0031965	cellular_component	nuclear membrane
C	0042803	molecular_function	protein homodimerization activity
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0043456	biological_process	regulation of pentose-phosphate shunt
C	0045177	cellular_component	apical part of cell
C	0047022	molecular_function	7-beta-hydroxysteroid dehydrogenase (NADP+) activity
C	0050661	molecular_function	NADP binding
C	0070524	molecular_function	11-beta-hydroxysteroid dehydrogenase (NADP+) activity
C	0102196	molecular_function	cortisol dehydrogenase activity
D	0005496	molecular_function	steroid binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006704	biological_process	glucocorticoid biosynthetic process
D	0006706	biological_process	steroid catabolic process
D	0006713	biological_process	glucocorticoid catabolic process
D	0008202	biological_process	steroid metabolic process
D	0008212	biological_process	mineralocorticoid metabolic process
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0030324	biological_process	lung development
D	0031965	cellular_component	nuclear membrane
D	0042803	molecular_function	protein homodimerization activity
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0043456	biological_process	regulation of pentose-phosphate shunt
D	0045177	cellular_component	apical part of cell
D	0047022	molecular_function	7-beta-hydroxysteroid dehydrogenase (NADP+) activity
D	0050661	molecular_function	NADP binding
D	0070524	molecular_function	11-beta-hydroxysteroid dehydrogenase (NADP+) activity
D	0102196	molecular_function	cortisol dehydrogenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 2KG A 301

Chain	Residue
A	ILE121
A	ALA233
A	NDP302
B	TYR284
A	THR124
A	SER170
A	TYR177
A	TYR183
A	LEU215
A	GLY216
A	LEU217
A	ILE231

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NDP A 302

Chain	Residue
A	GLY41
A	SER43
A	LYS44
A	GLY45
A	ILE46
A	ALA65
A	ARG66
A	SER67
A	THR92
A	MET93
A	ASN119
A	ILE121
A	ILE168
A	SER169
A	TYR183
A	LYS187
A	LEU215
A	GLY216
A	LEU217
A	ILE218
A	THR220
A	THR222
A	ALA223
A	2KG301
A	HOH403

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	LYS44
A	GLY45
A	ARG48
A	THR220
A	GLU221
A	LYS238

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 2KG B 301

Chain	Residue
A	TYR284
B	ILE121
B	THR124
B	SER170
B	TYR177
B	TYR183
B	LEU215
B	GLY216
B	LEU217
B	ILE227
B	ILE231
B	NDP302

site_id	AC5
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NDP B 302

Chain	Residue
B	GLY41
B	SER43
B	LYS44
B	GLY45
B	ILE46
B	ALA65
B	ARG66
B	SER67
B	MET93
B	ASN119
B	ILE121
B	ILE168
B	SER169
B	SER170
B	TYR183
B	LYS187
B	LEU215
B	GLY216
B	LEU217
B	ILE218
B	THR220
B	THR222
B	ALA223
B	2KG301

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 303

Chain	Residue
B	LYS44
B	GLY45
B	ARG48
B	THR220
B	GLU221
B	LYS238

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 304

Chain	Residue
B	ARG66
B	THR122
B	GLN123

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 2KG C 301

Chain	Residue
D	TYR284
C	ILE121
C	THR124
C	SER170
C	TYR177
C	TYR183
C	LEU215
C	GLY216
C	LEU217
C	THR222
C	ILE231
C	NDP302

site_id	AC9
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NDP C 302

Chain	Residue
C	GLY41
C	SER43
C	LYS44
C	GLY45
C	ILE46
C	ALA65
C	ARG66
C	SER67
C	GLY91
C	THR92
C	MET93
C	ASN119
C	ILE121
C	ILE168
C	SER169
C	SER170
C	TYR183
C	LYS187
C	LEU215
C	GLY216
C	LEU217
C	ILE218
C	THR220
C	THR222
C	ALA223
C	2KG301

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 303

Chain	Residue
C	ARG66
C	THR122
C	GLN123

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 304

Chain	Residue
C	LYS44
C	GLY45
C	ARG48
C	THR220
C	GLU221
C	LYS238

site_id	BC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 2KG D 301

Chain	Residue
C	TYR284
D	ILE121
D	THR124
D	SER170
D	TYR177
D	TYR183
D	LEU215
D	GLY216
D	LEU217
D	ILE227
D	ILE231
D	ALA233
D	NDP302

site_id	BC4
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NDP D 302

Chain	Residue
D	GLY41
D	SER43
D	LYS44
D	GLY45
D	ILE46
D	ALA65
D	ARG66
D	SER67
D	THR92
D	MET93
D	ASN119
D	ILE121
D	ILE168
D	SER169
D	SER170
D	TYR183
D	LYS187
D	LEU215
D	GLY216
D	LEU217
D	ILE218
D	THR220
D	THR222
D	ALA223
D	2KG301

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 303

Chain	Residue
D	GLY45
D	ARG48
D	THR220
D	GLU221
D	LYS238

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SlagkvtypmVapYSASKFALdGFFsTIR

Chain	Residue	Details
A	SER170-ARG198

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1068
Details	TOPO_DOM: Lumenal => ECO:0000255

Chain	Residue	Details
A	GLU25-ASN292
B	GLU25-ASN292
C	GLU25-ASN292
D	GLU25-ASN292

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	TYR183
B	TYR183
C	TYR183
D	TYR183

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING:

Chain	Residue	Details
A	GLY41
B	TYR183
C	GLY41
C	THR92
C	ASN119
C	SER170
C	TYR183
D	GLY41
D	THR92
D	ASN119
D	SER170
A	THR92
D	TYR183
A	ASN119
A	SER170
A	TYR183
B	GLY41
B	THR92
B	ASN119
B	SER170

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P28845

Chain	Residue	Details
A	ILE218
B	ILE218
C	ILE218
D	ILE218

site_id	SWS_FT_FI5
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN162
A	ASN207
B	ASN162
B	ASN207
C	ASN162
C	ASN207
D	ASN162
D	ASN207

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)