4NMH
11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005496 | molecular_function | steroid binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006704 | biological_process | glucocorticoid biosynthetic process |
| A | 0006706 | biological_process | steroid catabolic process |
| A | 0006713 | biological_process | glucocorticoid catabolic process |
| A | 0008212 | biological_process | mineralocorticoid metabolic process |
| A | 0030324 | biological_process | lung development |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043456 | biological_process | regulation of pentose-phosphate shunt |
| A | 0045177 | cellular_component | apical part of cell |
| A | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| B | 0005496 | molecular_function | steroid binding |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006704 | biological_process | glucocorticoid biosynthetic process |
| B | 0006706 | biological_process | steroid catabolic process |
| B | 0006713 | biological_process | glucocorticoid catabolic process |
| B | 0008212 | biological_process | mineralocorticoid metabolic process |
| B | 0030324 | biological_process | lung development |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043456 | biological_process | regulation of pentose-phosphate shunt |
| B | 0045177 | cellular_component | apical part of cell |
| B | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| C | 0005496 | molecular_function | steroid binding |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0006704 | biological_process | glucocorticoid biosynthetic process |
| C | 0006706 | biological_process | steroid catabolic process |
| C | 0006713 | biological_process | glucocorticoid catabolic process |
| C | 0008212 | biological_process | mineralocorticoid metabolic process |
| C | 0030324 | biological_process | lung development |
| C | 0031965 | cellular_component | nuclear membrane |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0043456 | biological_process | regulation of pentose-phosphate shunt |
| C | 0045177 | cellular_component | apical part of cell |
| C | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| C | 0050661 | molecular_function | NADP binding |
| C | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| D | 0005496 | molecular_function | steroid binding |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0005789 | cellular_component | endoplasmic reticulum membrane |
| D | 0006704 | biological_process | glucocorticoid biosynthetic process |
| D | 0006706 | biological_process | steroid catabolic process |
| D | 0006713 | biological_process | glucocorticoid catabolic process |
| D | 0008212 | biological_process | mineralocorticoid metabolic process |
| D | 0030324 | biological_process | lung development |
| D | 0031965 | cellular_component | nuclear membrane |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0043456 | biological_process | regulation of pentose-phosphate shunt |
| D | 0045177 | cellular_component | apical part of cell |
| D | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| D | 0050661 | molecular_function | NADP binding |
| D | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 2KG A 301 |
| Chain | Residue |
| A | ILE121 |
| A | ALA233 |
| A | NDP302 |
| B | TYR284 |
| A | THR124 |
| A | SER170 |
| A | TYR177 |
| A | TYR183 |
| A | LEU215 |
| A | GLY216 |
| A | LEU217 |
| A | ILE231 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NDP A 302 |
| Chain | Residue |
| A | GLY41 |
| A | SER43 |
| A | LYS44 |
| A | GLY45 |
| A | ILE46 |
| A | ALA65 |
| A | ARG66 |
| A | SER67 |
| A | THR92 |
| A | MET93 |
| A | ASN119 |
| A | ILE121 |
| A | ILE168 |
| A | SER169 |
| A | TYR183 |
| A | LYS187 |
| A | LEU215 |
| A | GLY216 |
| A | LEU217 |
| A | ILE218 |
| A | THR220 |
| A | THR222 |
| A | ALA223 |
| A | 2KG301 |
| A | HOH403 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 303 |
| Chain | Residue |
| A | LYS44 |
| A | GLY45 |
| A | ARG48 |
| A | THR220 |
| A | GLU221 |
| A | LYS238 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 2KG B 301 |
| Chain | Residue |
| A | TYR284 |
| B | ILE121 |
| B | THR124 |
| B | SER170 |
| B | TYR177 |
| B | TYR183 |
| B | LEU215 |
| B | GLY216 |
| B | LEU217 |
| B | ILE227 |
| B | ILE231 |
| B | NDP302 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NDP B 302 |
| Chain | Residue |
| B | GLY41 |
| B | SER43 |
| B | LYS44 |
| B | GLY45 |
| B | ILE46 |
| B | ALA65 |
| B | ARG66 |
| B | SER67 |
| B | MET93 |
| B | ASN119 |
| B | ILE121 |
| B | ILE168 |
| B | SER169 |
| B | SER170 |
| B | TYR183 |
| B | LYS187 |
| B | LEU215 |
| B | GLY216 |
| B | LEU217 |
| B | ILE218 |
| B | THR220 |
| B | THR222 |
| B | ALA223 |
| B | 2KG301 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 303 |
| Chain | Residue |
| B | LYS44 |
| B | GLY45 |
| B | ARG48 |
| B | THR220 |
| B | GLU221 |
| B | LYS238 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 304 |
| Chain | Residue |
| B | ARG66 |
| B | THR122 |
| B | GLN123 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 2KG C 301 |
| Chain | Residue |
| D | TYR284 |
| C | ILE121 |
| C | THR124 |
| C | SER170 |
| C | TYR177 |
| C | TYR183 |
| C | LEU215 |
| C | GLY216 |
| C | LEU217 |
| C | THR222 |
| C | ILE231 |
| C | NDP302 |
| site_id | AC9 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NDP C 302 |
| Chain | Residue |
| C | GLY41 |
| C | SER43 |
| C | LYS44 |
| C | GLY45 |
| C | ILE46 |
| C | ALA65 |
| C | ARG66 |
| C | SER67 |
| C | GLY91 |
| C | THR92 |
| C | MET93 |
| C | ASN119 |
| C | ILE121 |
| C | ILE168 |
| C | SER169 |
| C | SER170 |
| C | TYR183 |
| C | LYS187 |
| C | LEU215 |
| C | GLY216 |
| C | LEU217 |
| C | ILE218 |
| C | THR220 |
| C | THR222 |
| C | ALA223 |
| C | 2KG301 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 303 |
| Chain | Residue |
| C | ARG66 |
| C | THR122 |
| C | GLN123 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 304 |
| Chain | Residue |
| C | LYS44 |
| C | GLY45 |
| C | ARG48 |
| C | THR220 |
| C | GLU221 |
| C | LYS238 |
| site_id | BC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 2KG D 301 |
| Chain | Residue |
| C | TYR284 |
| D | ILE121 |
| D | THR124 |
| D | SER170 |
| D | TYR177 |
| D | TYR183 |
| D | LEU215 |
| D | GLY216 |
| D | LEU217 |
| D | ILE227 |
| D | ILE231 |
| D | ALA233 |
| D | NDP302 |
| site_id | BC4 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NDP D 302 |
| Chain | Residue |
| D | GLY41 |
| D | SER43 |
| D | LYS44 |
| D | GLY45 |
| D | ILE46 |
| D | ALA65 |
| D | ARG66 |
| D | SER67 |
| D | THR92 |
| D | MET93 |
| D | ASN119 |
| D | ILE121 |
| D | ILE168 |
| D | SER169 |
| D | SER170 |
| D | TYR183 |
| D | LYS187 |
| D | LEU215 |
| D | GLY216 |
| D | LEU217 |
| D | ILE218 |
| D | THR220 |
| D | THR222 |
| D | ALA223 |
| D | 2KG301 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 303 |
| Chain | Residue |
| D | GLY45 |
| D | ARG48 |
| D | THR220 |
| D | GLU221 |
| D | LYS238 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SlagkvtypmVapYSASKFALdGFFsTIR |
| Chain | Residue | Details |
| A | SER170-ARG198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 136 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P28845","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
