4NL4

PriA Helicase Bound to ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0000166	molecular_function	nucleotide binding
H	0003676	molecular_function	nucleic acid binding
H	0003677	molecular_function	DNA binding
H	0003678	molecular_function	DNA helicase activity
H	0004386	molecular_function	helicase activity
H	0005524	molecular_function	ATP binding
H	0006260	biological_process	DNA replication
H	0006269	biological_process	DNA replication, synthesis of primer
H	0006270	biological_process	DNA replication initiation
H	0006302	biological_process	double-strand break repair
H	0006310	biological_process	DNA recombination
H	0008270	molecular_function	zinc ion binding
H	0016787	molecular_function	hydrolase activity
H	0016853	molecular_function	isomerase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0043138	molecular_function	3'-5' DNA helicase activity
H	0046872	molecular_function	metal ion binding
H	1990077	cellular_component	primosome complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ADP H 801

Chain	Residue
H	ILE224
H	GLY226
H	GLY228
H	LYS229
H	THR230
H	GLU231
H	ARG263
H	LYS543

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 802

Chain	Residue
H	CYS447
H	CYS462
H	CYS465
H	CYS444

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 803

Chain	Residue
H	CYS435
H	CYS438
H	CYS475
H	CYS478

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	166
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_00983","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	62
Details	Region: {"description":"WH","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	175
Details	Region: {"description":"Helicase lobe 1","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	43
Details	Region: {"description":"Helicase lobe 2, N-terminus","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	54
Details	Region: {"description":"CRR","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Motif: {"description":"DEAH box","evidences":[{"source":"HAMAP-Rule","id":"MF_00983","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	14
Details	Motif: {"description":"Aromatic-rich loop (ARL)","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00983","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PDB","id":"4NL4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00983","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"4NL4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NL8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DGD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NL4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---