4NIE
Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE NBH A 601 |
| Chain | Residue |
| A | CYS285 |
| A | ALA368 |
| A | PHE377 |
| A | PHE378 |
| A | TYR502 |
| A | HOH735 |
| A | GLN286 |
| A | LEU287 |
| A | TRP317 |
| A | CYS320 |
| A | HIS323 |
| A | ARG364 |
| A | MET365 |
| A | ARG367 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMX A 602 |
| Chain | Residue |
| A | TRP314 |
| A | HIS490 |
| A | PRO491 |
| A | ILE492 |
| A | VAL493 |
| B | GLU333 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE NBH B 601 |
| Chain | Residue |
| B | CYS285 |
| B | GLN286 |
| B | LEU287 |
| B | TRP317 |
| B | CYS320 |
| B | HIS323 |
| B | LEU324 |
| B | ARG364 |
| B | MET365 |
| B | ARG367 |
| B | ALA368 |
| B | PHE377 |
| B | PHE378 |
| B | PHE388 |
| B | ILE400 |
| B | TYR502 |
| B | HOH720 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMX B 602 |
| Chain | Residue |
| A | GLU333 |
| B | TRP314 |
| B | LEU489 |
| B | HIS490 |
| B | PRO491 |
| B | ILE492 |
| B | VAL493 |
