4NI8
Crystal structure of 5-carboxyvanillate decarboxylase LigW from Sphingomonas paucimobilis complexed with Mn and 5-methoxyisophtalic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019748 | biological_process | secondary metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019748 | biological_process | secondary metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016831 | molecular_function | carboxy-lyase activity |
| C | 0019748 | biological_process | secondary metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016831 | molecular_function | carboxy-lyase activity |
| D | 0019748 | biological_process | secondary metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016829 | molecular_function | lyase activity |
| E | 0016831 | molecular_function | carboxy-lyase activity |
| E | 0019748 | biological_process | secondary metabolic process |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016829 | molecular_function | lyase activity |
| F | 0016831 | molecular_function | carboxy-lyase activity |
| F | 0019748 | biological_process | secondary metabolic process |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0016829 | molecular_function | lyase activity |
| G | 0016831 | molecular_function | carboxy-lyase activity |
| G | 0019748 | biological_process | secondary metabolic process |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0016829 | molecular_function | lyase activity |
| H | 0016831 | molecular_function | carboxy-lyase activity |
| H | 0019748 | biological_process | secondary metabolic process |
| H | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN A 401 |
| Chain | Residue |
| A | GLU7 |
| A | HIS173 |
| A | HIS226 |
| A | ASP296 |
| A | 1WB402 |
| A | HOH727 |
| A | HOH827 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 1WB A 402 |
| Chain | Residue |
| A | ARG45 |
| A | ALA77 |
| A | HIS173 |
| A | SER192 |
| A | ALA193 |
| A | TYR197 |
| A | HIS226 |
| A | ASP296 |
| A | TYR299 |
| A | MN401 |
| A | HOH558 |
| A | HOH563 |
| A | HOH612 |
| A | HOH613 |
| A | HOH648 |
| A | HOH827 |
| H | ARG237 |
| H | ASN244 |
| A | GLU7 |
| A | LEU34 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 403 |
| Chain | Residue |
| A | TYR240 |
| A | MET241 |
| A | GLY243 |
| A | ASN244 |
| A | HOH647 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 404 |
| Chain | Residue |
| A | LEU254 |
| A | LYS255 |
| A | LEU256 |
| A | EDO405 |
| A | HOH564 |
| A | HOH625 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 405 |
| Chain | Residue |
| A | LYS257 |
| A | GLU260 |
| A | EDO404 |
| A | HOH826 |
| D | PRO304 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 406 |
| Chain | Residue |
| A | ARG45 |
| A | PRO46 |
| A | ALA47 |
| A | MET48 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN B 401 |
| Chain | Residue |
| B | GLU7 |
| B | HIS173 |
| B | HIS226 |
| B | ASP296 |
| B | 1WB402 |
| B | HOH737 |
| B | HOH834 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 1WB B 402 |
| Chain | Residue |
| B | GLU7 |
| B | LEU34 |
| B | ARG45 |
| B | ALA77 |
| B | HIS173 |
| B | SER192 |
| B | ALA193 |
| B | HIS226 |
| B | ASP296 |
| B | TYR299 |
| B | MN401 |
| B | HOH513 |
| B | HOH573 |
| B | HOH608 |
| B | HOH834 |
| G | ARG237 |
| G | ASN244 |
| G | HOH501 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 403 |
| Chain | Residue |
| B | TYR240 |
| B | MET241 |
| B | GLY243 |
| B | ASN244 |
| B | HOH585 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN C 401 |
| Chain | Residue |
| C | GLU7 |
| C | HIS173 |
| C | HIS226 |
| C | ASP296 |
| C | 1WB402 |
| C | HOH811 |
| C | HOH822 |
| site_id | BC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 1WB C 402 |
| Chain | Residue |
| C | HOH663 |
| C | HOH822 |
| F | ARG237 |
| F | ASN244 |
| C | GLU7 |
| C | LEU34 |
| C | ARG45 |
| C | ALA77 |
| C | HIS173 |
| C | SER192 |
| C | ALA193 |
| C | TYR197 |
| C | HIS226 |
| C | ASP296 |
| C | TYR299 |
| C | MN401 |
| C | HOH583 |
| C | HOH592 |
| C | HOH604 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO C 403 |
| Chain | Residue |
| C | PRO315 |
| C | HOH501 |
| C | HOH504 |
| C | HOH636 |
| C | HOH812 |
| C | HOH826 |
| D | PRO315 |
| D | HOH531 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 404 |
| Chain | Residue |
| C | TYR240 |
| C | MET241 |
| C | GLY243 |
| C | ASN244 |
| C | HOH601 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 405 |
| Chain | Residue |
| C | ARG45 |
| C | PRO46 |
| C | ALA47 |
| C | MET48 |
| C | ARG51 |
| C | HOH666 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN D 401 |
| Chain | Residue |
| D | GLU7 |
| D | HIS173 |
| D | HIS226 |
| D | ASP296 |
| D | 1WB402 |
| D | HOH747 |
| site_id | BC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 1WB D 402 |
| Chain | Residue |
| D | GLU7 |
| D | LEU34 |
| D | ARG45 |
| D | ALA77 |
| D | HIS173 |
| D | ALA193 |
| D | TYR197 |
| D | HIS226 |
| D | ASP296 |
| D | TYR299 |
| D | MN401 |
| D | HOH544 |
| D | HOH551 |
| D | HOH556 |
| D | HOH581 |
| D | HOH593 |
| E | ARG237 |
| E | ASN244 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 403 |
| Chain | Residue |
| D | TYR240 |
| D | MET241 |
| D | GLY243 |
| D | ASN244 |
| D | HOH694 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN E 401 |
| Chain | Residue |
| E | GLU7 |
| E | HIS173 |
| E | HIS226 |
| E | ASP296 |
| E | 1WB402 |
| E | HOH834 |
| E | HOH846 |
| site_id | CC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 1WB E 402 |
| Chain | Residue |
| D | ARG237 |
| D | ASN244 |
| E | GLU7 |
| E | LEU34 |
| E | ARG45 |
| E | ALA77 |
| E | HIS173 |
| E | SER192 |
| E | ALA193 |
| E | TYR197 |
| E | HIS226 |
| E | ASP296 |
| E | TYR299 |
| E | MN401 |
| E | HOH583 |
| E | HOH588 |
| E | HOH596 |
| E | HOH603 |
| E | HOH622 |
| E | HOH846 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL E 403 |
| Chain | Residue |
| E | TYR240 |
| E | MET241 |
| E | GLY243 |
| E | ASN244 |
| E | HOH628 |
| site_id | CC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN F 401 |
| Chain | Residue |
| F | GLU7 |
| F | HIS173 |
| F | HIS226 |
| F | ASP296 |
| F | 1WB402 |
| F | HOH817 |
| F | HOH821 |
| site_id | CC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 1WB F 402 |
| Chain | Residue |
| C | ARG237 |
| C | ASN244 |
| F | GLU7 |
| F | LEU34 |
| F | ARG45 |
| F | ALA77 |
| F | HIS173 |
| F | SER192 |
| F | ALA193 |
| F | TYR197 |
| F | HIS226 |
| F | ASP296 |
| F | TYR299 |
| F | MN401 |
| F | HOH570 |
| F | HOH576 |
| F | HOH614 |
| F | HOH623 |
| F | HOH639 |
| F | HOH821 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL F 403 |
| Chain | Residue |
| F | ASP152 |
| F | HIS157 |
| F | SER211 |
| F | GLY212 |
| F | ARG216 |
| F | HOH829 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO F 404 |
| Chain | Residue |
| F | TYR240 |
| F | MET241 |
| F | GLY243 |
| F | ASN244 |
| F | HOH617 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO F 405 |
| Chain | Residue |
| F | GLU58 |
| F | GLU62 |
| F | SER65 |
| F | HOH605 |
| F | HOH649 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO F 406 |
| Chain | Residue |
| F | ARG45 |
| F | PRO46 |
| F | ALA47 |
| F | MET48 |
| F | ARG51 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO F 407 |
| Chain | Residue |
| F | HIS276 |
| F | GLN307 |
| F | PHE308 |
| F | THR311 |
| F | HOH561 |
| F | HOH745 |
| G | ARG263 |
| site_id | DC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN G 401 |
| Chain | Residue |
| G | GLU7 |
| G | HIS173 |
| G | HIS226 |
| G | ASP296 |
| G | 1WB402 |
| G | HOH733 |
| G | HOH823 |
| site_id | DC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 1WB G 402 |
| Chain | Residue |
| B | ARG237 |
| G | GLU7 |
| G | LEU34 |
| G | ARG45 |
| G | ALA77 |
| G | HIS173 |
| G | SER192 |
| G | ALA193 |
| G | TYR197 |
| G | HIS226 |
| G | ASP296 |
| G | TYR299 |
| G | MN401 |
| G | HOH530 |
| G | HOH566 |
| G | HOH592 |
| G | HOH608 |
| G | HOH823 |
| site_id | DC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO G 403 |
| Chain | Residue |
| G | LEU1 |
| G | ARG310 |
| G | GLU316 |
| G | LYS319 |
| G | HOH773 |
| G | HOH821 |
| H | PRO288 |
| H | GLU289 |
| H | MET321 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO G 404 |
| Chain | Residue |
| G | GLU58 |
| G | GLU62 |
| G | HOH822 |
| G | HOH824 |
| H | PRO218 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO G 405 |
| Chain | Residue |
| G | TYR240 |
| G | MET241 |
| G | GLY243 |
| G | ASN244 |
| G | HOH604 |
| site_id | DC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN H 401 |
| Chain | Residue |
| H | GLU7 |
| H | HIS173 |
| H | HIS226 |
| H | ASP296 |
| H | 1WB402 |
| H | HOH820 |
| H | HOH821 |
| site_id | DC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 1WB H 402 |
| Chain | Residue |
| A | ARG237 |
| A | ASN244 |
| H | GLU7 |
| H | LEU34 |
| H | ARG45 |
| H | ALA77 |
| H | HIS173 |
| H | SER192 |
| H | ALA193 |
| H | TYR197 |
| H | HIS226 |
| H | ASP296 |
| H | TYR299 |
| H | MN401 |
| H | HOH531 |
| H | HOH574 |
| H | HOH597 |
| H | HOH662 |
| H | HOH821 |
| site_id | DC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO H 403 |
| Chain | Residue |
| G | SER0 |
| G | ARG310 |
| H | GLU289 |
| H | ARG329 |
| H | HOH631 |
| site_id | DC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO H 404 |
| Chain | Residue |
| H | ARG45 |
| H | PRO46 |
| H | ALA47 |
| H | MET48 |
| H | ARG51 |
