4NHD
Crystal structure of beta-ketoacyl-ACP synthase III (FabH) from Vibrio Cholerae in complex with Coenzyme A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
| B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
| C | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
| D | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE COA A 401 |
| Chain | Residue |
| A | THR28 |
| A | LEU189 |
| A | MET206 |
| A | GLY208 |
| A | ASN209 |
| A | VAL211 |
| A | PHE212 |
| A | HIS243 |
| A | ALA245 |
| A | ASN246 |
| A | ARG248 |
| A | TRP32 |
| A | ASN273 |
| A | HOH651 |
| A | HOH723 |
| A | HOH751 |
| A | HOH785 |
| D | LYS213 |
| A | ARG36 |
| A | SCY112 |
| A | ARG151 |
| A | SER152 |
| A | ILE155 |
| A | LEU156 |
| A | PHE157 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 402 |
| Chain | Residue |
| A | ASN48 |
| A | ASP53 |
| A | HOH717 |
| A | HOH818 |
| A | HOH819 |
| A | HOH821 |
| A | HOH822 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 403 |
| Chain | Residue |
| A | ASN231 |
| A | HOH606 |
| A | HOH719 |
| A | HOH800 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE COA B 401 |
| Chain | Residue |
| B | THR28 |
| B | TRP32 |
| B | ARG36 |
| B | THR37 |
| B | SCY112 |
| B | ARG151 |
| B | SER152 |
| B | ILE155 |
| B | PHE157 |
| B | LEU189 |
| B | MET206 |
| B | GLY208 |
| B | ASN209 |
| B | VAL211 |
| B | ASN246 |
| B | ARG248 |
| B | HOH611 |
| B | HOH612 |
| B | HOH635 |
| B | HOH705 |
| B | HOH711 |
| B | HOH740 |
| B | HOH784 |
| B | HOH832 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 402 |
| Chain | Residue |
| B | ASN48 |
| B | ASP53 |
| B | HOH552 |
| B | HOH697 |
| B | HOH698 |
| B | HOH699 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 403 |
| Chain | Residue |
| B | ASP72 |
| B | ASP74 |
| B | HOH822 |
| B | HOH823 |
| B | HOH824 |
| B | HOH835 |
| site_id | AC7 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE COA C 401 |
| Chain | Residue |
| C | THR28 |
| C | TRP32 |
| C | ARG36 |
| C | SCY112 |
| C | ARG151 |
| C | SER152 |
| C | ILE155 |
| C | LEU189 |
| C | MET206 |
| C | GLY208 |
| C | ASN209 |
| C | VAL211 |
| C | PHE212 |
| C | HIS243 |
| C | ALA245 |
| C | ASN246 |
| C | ARG248 |
| C | ILE249 |
| C | ASN273 |
| C | PHE303 |
| C | HOH678 |
| C | HOH716 |
| C | HOH721 |
| C | HOH756 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 402 |
| Chain | Residue |
| C | HOH830 |
| C | HOH831 |
| C | HOH832 |
| C | ASP72 |
| C | ASP74 |
| C | HOH829 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 403 |
| Chain | Residue |
| C | ASN48 |
| C | ASP53 |
| C | HOH707 |
| C | HOH835 |
| C | HOH837 |
| C | HOH838 |
| site_id | BC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE COA D 401 |
| Chain | Residue |
| D | THR28 |
| D | TRP32 |
| D | ARG36 |
| D | SCY112 |
| D | ARG151 |
| D | SER152 |
| D | ILE155 |
| D | LEU156 |
| D | GLY208 |
| D | ASN209 |
| D | HIS243 |
| D | ALA245 |
| D | ASN246 |
| D | ILE249 |
| D | ASN273 |
| D | PHE303 |
| D | HOH634 |
| D | HOH717 |
| D | HOH736 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 402 |
| Chain | Residue |
| D | ASN48 |
| D | ASP53 |
| D | HOH718 |
| D | HOH719 |
| D | HOH720 |
| D | HOH721 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 403 |
| Chain | Residue |
| D | ASP72 |
| D | ASP74 |
| D | HOH723 |
| D | HOH724 |
| D | HOH725 |
| D | HOH726 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 404 |
| Chain | Residue |
| D | ASN231 |
| D | HOH713 |
| D | HOH714 |
| D | HOH715 |
| D | HOH716 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA D 405 |
| Chain | Residue |
| A | HOH812 |
| D | GLY67 |
| D | HOH731 |
| D | HOH732 |
| D | HOH733 |
| D | HOH734 |
| D | HOH735 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01815 |
| Chain | Residue | Details |
| A | SCY112 | |
| D | SCY112 | |
| D | HIS243 | |
| D | ASN273 | |
| A | HIS243 | |
| A | ASN273 | |
| B | SCY112 | |
| B | HIS243 | |
| B | ASN273 | |
| C | SCY112 | |
| C | HIS243 | |
| C | ASN273 |
