Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4NFI

Crystal structure of human FPPS in complex with magnesium and JDS05120

Functional Information from GO Data
ChainGOidnamespacecontents
F0004659molecular_functionprenyltransferase activity
F0008299biological_processisoprenoid biosynthetic process
F0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
Functional Information from PDB Data
site_idAC1
Number of Residues29
DetailsBINDING SITE FOR RESIDUE JD5 F 401
ChainResidue
FPHE98
FTHR167
FGLN171
FLYS200
FTHR201
FASP243
FLYS257
FMG402
FMG403
FMG404
FHOH501
FPHE99
FHOH503
FHOH504
FHOH505
FHOH506
FHOH507
FHOH508
FHOH509
FHOH520
FHOH539
FHOH581
FALA102
FASP103
FMET106
FASP107
FARG112
FASN130
FASN133

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG F 402
ChainResidue
FASP103
FASP107
FJD5401
FMG404
FHOH502
FHOH503
FHOH505

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG F 403
ChainResidue
FASP243
FJD5401
FHOH501
FHOH504
FHOH508

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG F 404
ChainResidue
FASP103
FASP107
FJD5401
FMG402
FHOH506
FHOH509

Functional Information from PROSITE/UniProt
site_idPS00444
Number of Residues13
DetailsPOLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGefFQIqDDYlD
ChainResidueDetails
FMET235-ASP247

site_idPS00723
Number of Residues15
DetailsPOLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LVaDDim..DssltRRG
ChainResidueDetails
FLEU100-GLY114

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:16684881, ECO:0007744|PDB:1ZW5
ChainResidueDetails
FLYS57
FARG60
FGLN96
FASP103
FASP107
FARG113

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING:
ChainResidueDetails
FARG112
FLYS200
FTHR201
FGLN240
FLYS257

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
FLYS266

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Important for determining product chain length => ECO:0000250
ChainResidueDetails
FPHE98
FPHE99

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
FLYS57

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
FLYS287

227561

PDB entries from 2024-11-20

PDB statisticsPDBj update infoContact PDBjnumon