4NFG
K13R mutant of horse cytochrome c and yeast cytochrome c peroxidase complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0020037 | molecular_function | heme binding |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005758 | cellular_component | mitochondrial intermembrane space |
| B | 0005829 | cellular_component | cytosol |
| B | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| B | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| B | 0006915 | biological_process | apoptotic process |
| B | 0008289 | molecular_function | lipid binding |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0018063 | biological_process | cytochrome c-heme linkage |
| B | 0020037 | molecular_function | heme binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043065 | biological_process | positive regulation of apoptotic process |
| B | 0043280 | biological_process | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070069 | cellular_component | cytochrome complex |
| B | 0070469 | cellular_component | respirasome |
| B | 2001056 | biological_process | positive regulation of cysteine-type endopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE HEM A 301 |
| Chain | Residue |
| A | PRO44 |
| A | LEU177 |
| A | GLY178 |
| A | LYS179 |
| A | THR180 |
| A | HIS181 |
| A | ASN184 |
| A | SER185 |
| A | TRP191 |
| A | LEU232 |
| A | THR234 |
| A | ARG48 |
| A | HOH442 |
| A | HOH460 |
| A | HOH522 |
| A | TRP51 |
| A | PRO145 |
| A | ALA147 |
| A | LEU171 |
| A | MET172 |
| A | ALA174 |
| A | HIS175 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEC B 201 |
| Chain | Residue |
| A | ALA193 |
| B | ARG13 |
| B | CYS14 |
| B | GLN16 |
| B | CYS17 |
| B | HIS18 |
| B | THR28 |
| B | GLY29 |
| B | PRO30 |
| B | THR40 |
| B | GLY41 |
| B | TYR48 |
| B | THR49 |
| B | ASN52 |
| B | TRP59 |
| B | LEU64 |
| B | TYR67 |
| B | LEU68 |
| B | THR78 |
| B | LYS79 |
| B | MET80 |
| B | PHE82 |
| B | LEU94 |
| B | HOH346 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: covalent |
| Chain | Residue | Details |
| B | CYS14 | |
| B | CYS17 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue => ECO:0000255|PROSITE-ProRule:PRU00433, ECO:0000269|PubMed:5545094 |
| Chain | Residue | Details |
| B | HIS18 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| B | MET80 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylglycine => ECO:0000269|PubMed:14469771 |
| Chain | Residue | Details |
| B | GLY1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62894 |
| Chain | Residue | Details |
| B | TYR48 | |
| B | TYR97 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62897 |
| Chain | Residue | Details |
| B | LYS55 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62897 |
| Chain | Residue | Details |
| B | LYS72 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62897 |
| Chain | Residue | Details |
| B | LYS99 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 709 |
| Chain | Residue | Details |
| A | ARG48 | electrostatic stabiliser |
| A | HIS52 | electrostatic stabiliser, proton acceptor, proton donor |
| A | TRP191 | single electron acceptor, single electron donor |
