4NF5
Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and D-AP5
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GLY A 901 |
| Chain | Residue |
| A | PHE92 |
| A | PHE250 |
| A | PRO124 |
| A | LEU125 |
| A | THR126 |
| A | ARG131 |
| A | SER179 |
| A | SER180 |
| A | TRP223 |
| A | ASP224 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 902 |
| Chain | Residue |
| A | HIS272 |
| A | MET277 |
| A | GLU278 |
| A | ASP281 |
| A | ARG286 |
| A | HOH1138 |
| B | ILE239 |
| B | PHE240 |
| B | ALA241 |
| B | THR242 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 2JJ B 301 |
| Chain | Residue |
| B | HIS88 |
| B | SER114 |
| B | LEU115 |
| B | THR116 |
| B | ARG121 |
| B | GLY172 |
| B | SER173 |
| B | THR174 |
| B | TYR214 |
| B | GOL302 |
| B | HOH403 |
| B | HOH409 |
| B | HOH480 |
| B | HOH527 |
| B | HOH684 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 302 |
| Chain | Residue |
| B | THR116 |
| B | GLY135 |
| B | ILE136 |
| B | SER173 |
| B | THR174 |
| B | ASP215 |
| B | 2JJ301 |
| B | HOH649 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 303 |
| Chain | Residue |
| A | ASN274 |
| B | ASN46 |
| B | ASN47 |
| B | SER48 |
| B | ASN181 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 39 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:B7ZSK1 |
| Chain | Residue | Details |
| B | ASP159-ARG179 | |
| B | CYS229-ALA248 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 27 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| B | ASN180-SER203 | |
| B | GLY224-GLY228 | |
| A | ASP224 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:B7ZSK1 |
| Chain | Residue | Details |
| B | LEU204-ALA223 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY |
| Chain | Residue | Details |
| B | SER114 | |
| A | ASN100 | |
| A | ASN166 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0000269|PubMed:27618671, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY |
| Chain | Residue | Details |
| B | ARG121 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8 |
| Chain | Residue | Details |
| B | SER173 | |
| B | TYR214 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Functional determinant of NMDA receptors => ECO:0000250 |
| Chain | Residue | Details |
| B | ALA217 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN46 | |
| B | ASN47 | |
| B | THR144 | |
| B | ASN171 |
