4NF2
Crystal structure of anabolic ornithine carbamoyltransferase from Bacillus anthracis in complex with carbamoyl phosphate and L-norvaline
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006526 | biological_process | L-arginine biosynthetic process |
| A | 0006591 | biological_process | ornithine metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| A | 0019240 | biological_process | citrulline biosynthetic process |
| A | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| B | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006526 | biological_process | L-arginine biosynthetic process |
| B | 0006591 | biological_process | ornithine metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0019240 | biological_process | citrulline biosynthetic process |
| B | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| C | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006526 | biological_process | L-arginine biosynthetic process |
| C | 0006591 | biological_process | ornithine metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0016597 | molecular_function | amino acid binding |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| C | 0019240 | biological_process | citrulline biosynthetic process |
| C | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CP A 401 |
| Chain | Residue |
| A | SER57 |
| A | ARG297 |
| A | NVA402 |
| B | GLN84 |
| A | THR58 |
| A | ARG59 |
| A | THR60 |
| A | ARG108 |
| A | HIS135 |
| A | GLN138 |
| A | CYS269 |
| A | LEU270 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NVA A 402 |
| Chain | Residue |
| A | ASN165 |
| A | ASN166 |
| A | ASP230 |
| A | SER234 |
| A | MET235 |
| A | LEU270 |
| A | CP401 |
| A | HOH513 |
| A | HOH601 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 403 |
| Chain | Residue |
| A | ILE289 |
| A | VAL290 |
| A | PHE291 |
| A | GLU292 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 404 |
| Chain | Residue |
| A | SER234 |
| A | GLY236 |
| A | HOH513 |
| A | HOH540 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 401 |
| Chain | Residue |
| B | ILE289 |
| B | PHE291 |
| B | GLU292 |
| B | HOH619 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE NVA B 402 |
| Chain | Residue |
| B | LEU130 |
| B | ASN165 |
| B | ASN166 |
| B | ASP230 |
| B | SER234 |
| B | MET235 |
| B | LEU270 |
| B | CP403 |
| B | HOH645 |
| B | HOH666 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CP B 403 |
| Chain | Residue |
| B | SER57 |
| B | THR58 |
| B | ARG59 |
| B | THR60 |
| B | ARG108 |
| B | HIS135 |
| B | GLN138 |
| B | CYS269 |
| B | LEU270 |
| B | ARG297 |
| B | NVA402 |
| C | GLN84 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 404 |
| Chain | Residue |
| B | SER234 |
| B | GLY236 |
| B | HOH666 |
| B | HOH667 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CP C 401 |
| Chain | Residue |
| A | GLN84 |
| C | SER57 |
| C | THR58 |
| C | ARG59 |
| C | THR60 |
| C | ARG108 |
| C | HIS135 |
| C | GLN138 |
| C | CYS269 |
| C | LEU270 |
| C | ARG297 |
| C | NVA402 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE NVA C 402 |
| Chain | Residue |
| A | HOH520 |
| C | LEU130 |
| C | ASN165 |
| C | ASN166 |
| C | ASP230 |
| C | SER234 |
| C | MET235 |
| C | LEU270 |
| C | CP401 |
| C | HOH517 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL C 403 |
| Chain | Residue |
| A | HOH689 |
| C | ILE289 |
| C | PHE291 |
| C | GLU292 |
| C | HOH632 |
Functional Information from PROSITE/UniProt
| site_id | PS00097 |
| Number of Residues | 8 |
| Details | CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FdKhSTRT |
| Chain | Residue | Details |
| A | PHE53-THR60 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 39 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2013","submissionDatabase":"PDB data bank","title":"Crystal structures and kinetic properties of anabolic ornithine carbamoyltransferase from human pathogens Vibrio vulnificus and Bacillus anthracis.","authors":["Shabalin I.G.","Handing K.","Cymborowski M.T.","Stam J.","Winsor J.","Shuvalova L.","Anderson W.F.","Minor W."]}},{"source":"PDB","id":"4NF2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
