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4NEJ

Small molecular fragment bound to crystal contact interface of Interleukin-2

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0002366biological_processleukocyte activation involved in immune response
A0002639biological_processpositive regulation of immunoglobulin production
A0002903biological_processnegative regulation of B cell apoptotic process
A0005125molecular_functioncytokine activity
A0005134molecular_functioninterleukin-2 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006366biological_processtranscription by RNA polymerase II
A0006955biological_processimmune response
A0007155biological_processcell adhesion
A0007186biological_processG protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007267biological_processcell-cell signaling
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0010467biological_processgene expression
A0019209molecular_functionkinase activator activity
A0030101biological_processnatural killer cell activation
A0030217biological_processT cell differentiation
A0030246molecular_functioncarbohydrate binding
A0030307biological_processpositive regulation of cell growth
A0030890biological_processpositive regulation of B cell proliferation
A0031851molecular_functionkappa-type opioid receptor binding
A0032729biological_processpositive regulation of type II interferon production
A0032740biological_processpositive regulation of interleukin-17 production
A0034105biological_processpositive regulation of tissue remodeling
A0038110biological_processinterleukin-2-mediated signaling pathway
A0042098biological_processT cell proliferation
A0042102biological_processpositive regulation of T cell proliferation
A0042104biological_processpositive regulation of activated T cell proliferation
A0043066biological_processnegative regulation of apoptotic process
A0043208molecular_functionglycosphingolipid binding
A0045471biological_processresponse to ethanol
A0045582biological_processpositive regulation of T cell differentiation
A0045591biological_processpositive regulation of regulatory T cell differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046013biological_processregulation of T cell homeostatic proliferation
A0046651biological_processlymphocyte proliferation
A0048304biological_processpositive regulation of isotype switching to IgG isotypes
A0050672biological_processnegative regulation of lymphocyte proliferation
A0050728biological_processnegative regulation of inflammatory response
A0050729biological_processpositive regulation of inflammatory response
A0050798biological_processactivated T cell proliferation
A0060999biological_processpositive regulation of dendritic spine development
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0097696biological_processcell surface receptor signaling pathway via STAT
A1900100biological_processpositive regulation of plasma cell differentiation
A1901327biological_processresponse to tacrolimus
A2000320biological_processnegative regulation of T-helper 17 cell differentiation
A2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 2K1 A 201
ChainResidue
AHIS16
AHOH330
ALEU19
AASP20
AMET23
ATHR41
APHE42
ALYS43
APHE44
AASN88

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE 2K1 A 202
ChainResidue
AGLU15
AARG38
APHE42
AVAL69
ALEU72
AALA73

Functional Information from PROSITE/UniProt
site_idPS00424
Number of Residues13
DetailsINTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL
ChainResidueDetails
ATHR51-LEU63

224572

PDB entries from 2024-09-04

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