Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0007586 | biological_process | digestion |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0097180 | cellular_component | serine protease inhibitor complex |
| A | 0097655 | molecular_function | serpin family protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 301 |
| Chain | Residue |
| A | GLU52 |
| A | ASN54 |
| A | VAL57 |
| A | GLU62 |
| A | HOH402 |
| A | HOH410 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE BEN A 302 |
| Chain | Residue |
| A | GLN174 |
| A | SER177 |
| A | TRP193 |
| A | GLY194 |
| A | GLY196 |
| A | GLY204 |
| A | HOH428 |
| A | HOH808 |
| A | HOH810 |
| A | ASP171 |
| A | SER172 |
| A | CYS173 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EDO A 303 |
| Chain | Residue |
| A | ARG49 |
| A | ILE55 |
| A | ASN56 |
| A | VAL58 |
| A | VAL72 |
| A | HIS73 |
| A | PRO74 |
| A | EDO304 |
| A | HOH410 |
| A | HOH438 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 304 |
| Chain | Residue |
| A | TYR22 |
| A | HIS23 |
| A | ILE55 |
| A | ASN56 |
| A | VAL72 |
| A | EDO303 |
| A | HOH449 |
| A | HOH712 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 305 |
| Chain | Residue |
| A | CYS109 |
| A | ALA110 |
| A | PHE161 |
| A | GLN188 |
| A | LYS208 |
| A | HOH417 |
| A | HOH775 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 306 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 307 |
| Chain | Residue |
| A | VAL58 |
| A | ASN77 |
| A | ASN79 |
| A | HOH424 |
| A | HOH639 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EDO A 308 |
| Chain | Residue |
| A | GLY45 |
| A | ALA67 |
| A | SER68 |
| A | LYS69 |
| A | SER130 |
| A | TYR131 |
| A | HOH645 |
| A | HOH726 |
| A | HOH805 |
| A | HOH817 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 309 |
| Chain | Residue |
| A | HIS40 |
| A | GLN174 |
| A | GLY175 |
| A | SER177 |
| A | HOH602 |
| A | HOH642 |
| A | HOH644 |
| A | HOH674 |
| A | HOH694 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 310 |
| Chain | Residue |
| A | PRO106 |
| A | THR107 |
| A | SER108 |
| A | GLY128 |
| A | LYS186 |
| A | GLN188 |
| A | IMD314 |
| A | HOH441 |
| A | HOH627 |
| A | HOH766 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 311 |
| Chain | Residue |
| A | LYS149 |
| A | PRO153 |
| A | GLY154 |
| A | HOH430 |
| A | HOH584 |
| A | HOH604 |
| A | HOH776 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 312 |
| Chain | Residue |
| A | LYS69 |
| A | LYS89 |
| A | THR129 |
| A | HOH525 |
| A | HOH623 |
| A | HOH684 |
| A | HOH725 |
| A | HOH766 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 313 |
| Chain | Residue |
| A | LYS125 |
| A | SER126 |
| A | SER127 |
| A | HOH697 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE IMD A 314 |
| Chain | Residue |
| A | SER126 |
| A | GLY128 |
| A | GLN174 |
| A | SER184 |
| A | LYS186 |
| A | CYS197 |
| A | SO4310 |
| A | ASN123 |
| A | LYS125 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC |
| Chain | Residue | Details |
| A | VAL36-CYS41 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV |
| Chain | Residue | Details |
| A | ASP171-VAL182 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS40 | |
| A | ASP84 | |
| A | SER177 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | VAL57 | |
| A | GLU62 | |
| A | ASP171 | |
| A | GLN174 | |
| A | SER177 | |
| A | GLU52 | |
| A | ASN54 | |
