4N9Y

Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E748Q

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
A	0005975	biological_process	carbohydrate metabolic process
A	0006282	biological_process	regulation of DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1001

Chain	Residue
A	LYS444
A	LEU447
A	ARG824
A	ARG902
A	HOH1185

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1002

Chain	Residue
A	ASN639
A	HOH1189
A	ARG528
A	TYR557
A	PRO636
A	ARG637

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1003

Chain	Residue
A	ASN733
A	ARG734
A	HIS821
A	HOH1128
A	HOH1233

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1004

Chain	Residue
A	ARG656
A	GLY742
A	ALA743
A	GLY744
A	HIS951

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1005

Chain	Residue
A	SER466
A	ARG468

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1006

Chain	Residue
A	ARG637
A	LYS643
A	SER644
A	GLU645
A	HOH1262

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE V3L A 1007

Chain	Residue
A	PRO469
A	VAL475
A	VAL477
A	ARG478
A	VAL479
A	ASP480
A	PHE491
A	THR493
A	HOH1276

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	118
Details	Domain: {"description":"PARG helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	202
Details	Domain: {"description":"PARG catalytic Macro","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	185
Details	Region: {"description":"Catalytic","evidences":[{"source":"UniProtKB","id":"Q86W56","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"Q86W56","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q86W56","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9QYM2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---